Review: Role of NONO Gene from DBHS Complex and its Interaction with PIN1 in Cancer


Authors : Sayed Tariq Pachakhan; HasamudinSayedi; Samira Hamidi

Volume/Issue : Volume 8 - 2023, Issue 1 - January

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3ktGe30

DOI : https://doi.org/10.5281/zenodo.7554173

Paraspeckle are sub-nuclear bodies found in the interchromatin space of mammalian cells, made from the interaction of non-coding RNA and DBHS (Drosophila behavior human splicing) complex. DBHS consists of p54NRB/NONO, PSPC1, and PSF/SFPQ proteins. Each protein of the DBHS complex contains RRM1/2, NOPS, and the Coiled-coil domain.Amongstthe DBHS complex, NONO protein is involved in breast, prostate, and malignant melanoma progress. NONO gene is engaged in various biological processes, including RNA splicing and editing, DNA unwinding and repairing, and gene transcription. NONO can interact withSFPQ and PSPC1 in the DBHS complex as heterodimers and homodimers. In addition, NONO can also interact with Sterol regulatory-element binding proteins (SREBPs) and stabilize them. (SREBPs) activate genes encoding key enzymes responsible for the biosynthesis of fatty acid and cholesterol in breast cancer. PIN1 and SUPT5H are oncogenic proteins;the function of PIN1 is defined by its two domains: the WW domain and the PPIase domain. NONOand SUPT5H interact withthe WW domain of the PIN1 protein, which induces the PPIase domain and promotes cancer. PIN1 stabilizes the NONO, and SUPT5H, contributing to breast cancer cell proliferation, migration, invasion, cell cycle, and apoptosis. Silencing NONO, PIN1, and SUPT5H can suppress tumor growth and be a good target for therapeutic purposes.

Keywords : NONO gene, DBHS Complex, PIN1, Cancer

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