A smart drug delivery system consists of intelligent nanocarriers, process selection, and relaxation techniques. This study highlights the recent novel development of Smart Drug Delivery Systems for a variety of technical nanocarriers, including liposomes, micelles, dendrimers, mesoporous silica nanoparticles, gold nanoparticles, super paramagnetic iron oxide nanoparticles, carbon nanotubes, and quantum dots and their impact on cancer treatments. This study is expected to be of widespread interest to those who are looking for new future research in this field and to those who are about to start their research into smart nano-carrierbased drug delivery. Smart Drug Delivery Systems could distribute drugs to low-dose sites and regulate means to remove the side effects that are otherwise induced by traditional drug delivery systems. Chemotherapy is widely used for treating cancer, which would be the world's second-largest cause of death.” Choosing the best strategies for cancer cell detection follows the selection of an acceptable kind of nanocarrier. SDDs identify cancer sites by using the physiochemical variations between cancer cells and healthy cells. The location of the cancer cells is described precisely by two main methods: passive targeting and active targeting. Passive targeting allows for the cancer site to be recognized implicitly by using the Enhanced Permeability (EPR) effect. Active targeting uses cancer cell surface receptors which are over expressed specifically for targeting cancer cells. The next move is to discharge drugs at a particular concentration at the stated site. Drugs can be released by external or internal stimulation from nanocarriers, depending on the shape and smartness of nano-carriers

Keywords : Novel techniques, smart drugs delivery system (SDDS), cancer, treatment, challenges.