Authors : Ahmed J. H. Almaliky; Rafid R. Al-Tuma; Yasir Riyadh Mohsin; Enas Ryad Mohsen

Volume/Issue : Volume 11 - 2026, Issue 10 - October

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Google Scholar : https://tinyurl.com/5c5w4958

DOI : https://doi.org/10.38124/ijisrt/26Oct132

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

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Abstract : Radioactive fluoride, fluidic channels, and functional sorbent materials interact in a number of ways during automated [¹ F] FDG synthesis. Nevertheless, it is still unclear how downstream radioactive material movement affects runto-run yield variability. This work used a FAST lab 2 platform connected to a PET trace 800 cyclotron to assess stageresolved F activity during automated FDG synthesis.

Keywords : FAST Lab2, Interfacial Transport, Surface Retention, Radioactive-Material Transfer, MA; Tc18, Materials Physics.

References :

1. Almaliky AJH, Algrifi MA, Hammood HF. Proton energy deposition and material-dependent selectivity in ¹⁸F-FDG production using a medical cyclotron PETtrace 800. Radiation Effects and Defects in Solids. 2026. doi:10.1080/10420150.2026.2692384.
2. Sowa AR, Jackson IM, Desmond TJ, et al. Futureproofing [¹⁸F] fludeoxyglucose manufacture at an Academic Medical Center. EJNMMI Radiopharmacy and Chemistry. 2018;3:12. doi:10.1186/s41181-018-0048-x.
3. Yu S. Review of ¹⁸F-FDG synthesis and quality control. Biomedical Imaging and Intervention Journal. 2006;2(4):e57. doi:10.2349/biij.2.4.e57.
4. Long JZ, Jacobson MS, Hung JC. Comparison of FASTlab 2 ^18F-FDG production using phosphate and citrate buffer cassettes. Journal of Nuclear Medicine Technology. 2013;41(1):32–34. doi:10.2967/jnmt.112.112649.
5. Huang YY, Taylor S, Kaczorowski J, et al. A two-center study for the quality control of [¹⁸F] FDG using FASTlab 2 phosphate cassettes. Annals of Nuclear Medicine. 2016;30(8):563–571. doi:10.1007/s12149-016-1097-4.
6. Hjelstuen OK, Svadberg A, Olberg DE, Rosser M. Standardization of fluorine-18 manufacturing processes: new scientific challenges for PET. European Journal of Pharmaceutics and Biopharmaceutics. 2011;78(3):307–313. doi: 10.1016/j.ejpb.2011.01.002.
7. Savisto N, Bergman J, Aromaa J, et al. Influence of transport line material on the molar activity of cyclotron produced [¹⁸F] fluoride. Nuclear Medicine and Biology. 2018;64–65:8–15. doi: 10.1016/j.nucmedbio.2018.06.004.
8. Perinelli C, Infantino A, Cicoria G, Pancaldi D, Marengo M, Mostacci D. Assessment of radionuclidic impurities in 2-[¹⁸F] fluoro-2-deoxy-D-glucose ([¹⁸F] FDG) synthesis with the GE FASTlab 2 synthesizer. Clinical and Translational Imaging. 2013;1(S1):S108. doi:10.1007/s40336-013-0002-6.
9. Gaspar L, Reich M, Kassai Z, Macasek F, Rodrigo L, Kruzliak P, Kovac P. Long-term quality assurance of [^18F]-fluorodeoxyglucose (FDG) manufacturing. American Journal of Nuclear Medicine and Molecular Imaging. 2016;6(3):154–165.
10. Menzel F, et al. Open-source flow setup for rapid and efficient [¹⁸F] fluoride drying for automation of PET tracer syntheses. Journal of Labelled Compounds and Radiopharmaceuticals. 2024. doi:10.1002/jlcr.4080.