Authors :
Udeh Owen Chikere; Nwobodo .O. Edwin; Udeh Emeka Ihechi; Agu Esther Chioma; Alor Oluchukwu Onyinyechukwu; ChukaOnwuokwu; Ngozi Cynthia; Ugwoke C.Chukwuma; Nwaefulu Kester Eluemunor
Volume/Issue :
Volume 6 - 2021, Issue 11 - November
Google Scholar :
http://bitly.ws/gu88
Scribd :
https://bit.ly/30l9yyZ
The wound healing properties of root extract
of Harungana madasgascariensis on Wistar rat was
studied. The excision wound was created on rats by
cutting away a 4.9cm2 full thickness of skin from a
determined area on the back of selected rat. The ethanol
extract of roots of H.Madagascariensis given orally at the
doses of 150mg/kg/day, 200mg/kg/day and 250mg/kg/day
for 14 consecutive days resulted in a fast wound
epithelization, which was more significant in the ones
that received a high dose of H.M. The result of wound
epithelization of the ones treated when compared to
control was statistically significant (p˂0.05). These
results were also supported by an increased Neutrophils
and Monocytes in the blood which was statistically
significant when compared to negative control. This fast
wound epithelization was as measured at days 1, 5 and
10 wound epithelization days until wound healing was
completed. These results suggested that
H.madagascariensiss extract was potent in management
of wound though the active ingredient/s responsible for
this action was yet to be known. Hence, suggests that
H.M contains products that aid the wound healing
process as described by folkloric medicine
Keywords :
Harungana madagascariensis, Wound Healing, Excision, Neutrophils, Monocytes