Wound Healing Properties of Root Extract of Harungana madagascariensis on Wistar Rat Model

Authors : Udeh Owen Chikere; Nwobodo .O. Edwin; Udeh Emeka Ihechi; Agu Esther Chioma; Alor Oluchukwu Onyinyechukwu; ChukaOnwuokwu; Ngozi Cynthia; Ugwoke C.Chukwuma; Nwaefulu Kester Eluemunor

Volume/Issue : Volume 6 - 2021, Issue 11 - November

Google Scholar : http://bitly.ws/gu88

Scribd : https://bit.ly/30l9yyZ

The wound healing properties of root extract of Harungana madasgascariensis on Wistar rat was studied. The excision wound was created on rats by cutting away a 4.9cm2 full thickness of skin from a determined area on the back of selected rat. The ethanol extract of roots of H.Madagascariensis given orally at the doses of 150mg/kg/day, 200mg/kg/day and 250mg/kg/day for 14 consecutive days resulted in a fast wound epithelization, which was more significant in the ones that received a high dose of H.M. The result of wound epithelization of the ones treated when compared to control was statistically significant (p˂0.05). These results were also supported by an increased Neutrophils and Monocytes in the blood which was statistically significant when compared to negative control. This fast wound epithelization was as measured at days 1, 5 and 10 wound epithelization days until wound healing was completed. These results suggested that H.madagascariensiss extract was potent in management of wound though the active ingredient/s responsible for this action was yet to be known. Hence, suggests that H.M contains products that aid the wound healing process as described by folkloric medicine

Keywords : Harungana madagascariensis, Wound Healing, Excision, Neutrophils, Monocytes


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