Authors :
Dr. D. Nagavalli; P. Ponguzhali; P. Nanthagopal
Volume/Issue :
Volume 8 - 2023, Issue 7 - July
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/mrzrbhz7
DOI :
https://doi.org/10.5281/zenodo.8276134
Abstract :
For the simultaneous quantification of
paracetamol, ambroxol hydrochloride, levocetirizine
dihydrochloride, and pseudoephedrine hydrochloride in
tablet dosage forms, a simple, specific, accurate, exact,
and cost-effective UV-method was devised. The analysis
was carried out using Cramer's rule and Gauss-Jorden
elimination using UV-spectroscopy of paracetamol,
ambroxol hydrochloride, levocetirizine dihydrochloride,
and pseudoephedrine hydrochloride as the solvent. The
absorbtion maximums for the four drugs of 243, 220,
264, and 257 nm were selected wavelenth. With a
regression coefficient of 0.999, a linear response
between (12ug-72ug/ml) was seen, and the percentage
R.S.D. values of 0.7073, 0.6484, 1.6358, and 0.7308 fall
within acceptable bounds. Method was approved in
accordance with ICH recommendations.
Keywords :
Paracetamol, Ambroxol Hydrochloride, Levocetirizine Dihydrochloride, Pseudoephedrine Hydrochloride, UV-Method.
For the simultaneous quantification of
paracetamol, ambroxol hydrochloride, levocetirizine
dihydrochloride, and pseudoephedrine hydrochloride in
tablet dosage forms, a simple, specific, accurate, exact,
and cost-effective UV-method was devised. The analysis
was carried out using Cramer's rule and Gauss-Jorden
elimination using UV-spectroscopy of paracetamol,
ambroxol hydrochloride, levocetirizine dihydrochloride,
and pseudoephedrine hydrochloride as the solvent. The
absorbtion maximums for the four drugs of 243, 220,
264, and 257 nm were selected wavelenth. With a
regression coefficient of 0.999, a linear response
between (12ug-72ug/ml) was seen, and the percentage
R.S.D. values of 0.7073, 0.6484, 1.6358, and 0.7308 fall
within acceptable bounds. Method was approved in
accordance with ICH recommendations.
Keywords :
Paracetamol, Ambroxol Hydrochloride, Levocetirizine Dihydrochloride, Pseudoephedrine Hydrochloride, UV-Method.
