Authors :
Vaishnavi Kulwal; Zara I. Mohamed; Varad P. Bhangui; Prohit Jumnani; Dr. Shraddha Kulkarni
Volume/Issue :
Volume 8 - 2023, Issue 5 - May
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/3MEHg7S
DOI :
https://doi.org/10.5281/zenodo.7950921
Abstract :
Hydrophobins are a group of small, low
molecular weight cysteine-rich fungal proteins found in
the hyphae walls of fungi. Due to their composition,
hydrophobins have the surface-modifying ability to
form an amphiphilic membrane at the hydrophobichydrophilic interface in an aqueous solution which can
be used to coat hydrophobic surfaces and change their
nature. This property has applications in increasing the
bioavailability of low aqueous solubility hydrophobic
compounds by preparation of nanosuspensions. The low
solubility hinders their efficacy in being used as
therapeutic drugs. The objective of this review is to
explore the medical application of hydrophobins in the
preparation of hydrophobin-drug nanosuspension in
order to increase the bioavailability of hydrophobic
drugs and to explore the stability of these
nanosuspensions using five hydrophobic therapeutics -
curcumin, nifedipine, cyclosporine, docetaxel, and
amphotericin.
Keywords :
Hydrophobin nano suspensions, Hydrophobic drugs, Amphotericin, Docetaxel, Nifedipine, Cyclosporine, Curcumin, Bioavailability
Hydrophobins are a group of small, low
molecular weight cysteine-rich fungal proteins found in
the hyphae walls of fungi. Due to their composition,
hydrophobins have the surface-modifying ability to
form an amphiphilic membrane at the hydrophobichydrophilic interface in an aqueous solution which can
be used to coat hydrophobic surfaces and change their
nature. This property has applications in increasing the
bioavailability of low aqueous solubility hydrophobic
compounds by preparation of nanosuspensions. The low
solubility hinders their efficacy in being used as
therapeutic drugs. The objective of this review is to
explore the medical application of hydrophobins in the
preparation of hydrophobin-drug nanosuspension in
order to increase the bioavailability of hydrophobic
drugs and to explore the stability of these
nanosuspensions using five hydrophobic therapeutics -
curcumin, nifedipine, cyclosporine, docetaxel, and
amphotericin.
Keywords :
Hydrophobin nano suspensions, Hydrophobic drugs, Amphotericin, Docetaxel, Nifedipine, Cyclosporine, Curcumin, Bioavailability