Authors :
Hamza Oualhadj; Nouhaila Moustahfid; Ayoub Rafei; Saliha Chelak; Abderrahmane Boukhira
Volume/Issue :
Volume 9 - 2024, Issue 5 - May
Google Scholar :
https://tinyurl.com/wvujf4k9
Scribd :
https://tinyurl.com/ypabdt4r
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24MAY2230
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Prealbumin, a multifunctional protein
synthesized primarily in the liver, serves as a critical
biomarker in clinical practice, offering insights into
nutritional status and prognostic outcomes. While its
precise physiological role remains incompletely
understood, prealbumin is known to facilitate hormone
transport, particularly of thyroxine, and contribute to
neuroprotection. Clinically, prealbumin levels are
sensitive indicators of recent changes in protein intake
and absorption, making them invaluable in guiding
therapeutic interventions. Alterations in prealbumin
levels have been associated with various medical
conditions, including chronic kidney disease, liver
disease, and cancer, emphasizing its prognostic
significance across diverse clinical contexts. we report a
case of a 42-year-old male with bipolar disorder
managed on lithium therapy, presenting with depressive
symptoms and unexpected hyperprealbuminemia.
Subsequent investigation revealed primary
hypothyroidism secondary to lithium intoxication,
highlighting the intricate relationship between lithium
therapy, prealbumin levels, and thyroid dysfunction. We
discuss the mechanisms and clinical implications of
lithium-induced hypothyroidism, emphasizing the
importance of considering thyroid function in patients
with elevated prealbumin levels. This case underscores
the necessity for vigilant monitoring and timely
intervention to optimize patient outcomes in cases of
lithium-induced thyroid dysfunction. Continued
research is crucial for elucidating the complex
interactions between prealbumin, lithium therapy, and
thyroid function, enhancing our understanding and
management of these metabolic disturbances.
Keywords :
Elevated Prealbumin; Lithium-Induced Hypothyroidism; Biomarkers; Clinical Implications.
References :
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- Liz, M.A., Coelho, T., Bellotti, V., Fernandez-Arias, M.I., Mallaina, P., Obici, L.: A Narrative Review of the Role of Transthyretin in Health and Disease, (2020)
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Prealbumin, a multifunctional protein
synthesized primarily in the liver, serves as a critical
biomarker in clinical practice, offering insights into
nutritional status and prognostic outcomes. While its
precise physiological role remains incompletely
understood, prealbumin is known to facilitate hormone
transport, particularly of thyroxine, and contribute to
neuroprotection. Clinically, prealbumin levels are
sensitive indicators of recent changes in protein intake
and absorption, making them invaluable in guiding
therapeutic interventions. Alterations in prealbumin
levels have been associated with various medical
conditions, including chronic kidney disease, liver
disease, and cancer, emphasizing its prognostic
significance across diverse clinical contexts. we report a
case of a 42-year-old male with bipolar disorder
managed on lithium therapy, presenting with depressive
symptoms and unexpected hyperprealbuminemia.
Subsequent investigation revealed primary
hypothyroidism secondary to lithium intoxication,
highlighting the intricate relationship between lithium
therapy, prealbumin levels, and thyroid dysfunction. We
discuss the mechanisms and clinical implications of
lithium-induced hypothyroidism, emphasizing the
importance of considering thyroid function in patients
with elevated prealbumin levels. This case underscores
the necessity for vigilant monitoring and timely
intervention to optimize patient outcomes in cases of
lithium-induced thyroid dysfunction. Continued
research is crucial for elucidating the complex
interactions between prealbumin, lithium therapy, and
thyroid function, enhancing our understanding and
management of these metabolic disturbances.
Keywords :
Elevated Prealbumin; Lithium-Induced Hypothyroidism; Biomarkers; Clinical Implications.