Authors : Aditi Khobragade; Bhagyashri Bhure

Volume/Issue : Volume 11 - 2026, Issue 2 - February

Google Scholar : https://tinyurl.com/nys8fsba

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DOI : https://doi.org/10.38124/ijisrt/26feb534

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Abstract : Sapindus mukorossi, commonly known as soapnut or reetha, is a medicinal plant that has been traditionally used for centuries in India, China, and Southeast Asia. Most scientific studies on this plant have focused on its fruits, while the medicinal potential of its leaves has received comparatively little attention. In recent years, increasing interest in plant-based therapies has encouraged further investigation of S. mukorossi leaves due to their unique composition of bioactive compounds. This review summarizes traditional knowledge, botanical information, and recent experimental studies to evaluate the medicinal importance of S. mukorossi leaf extracts. Phytochemical studies have consistently identified the presence of flavonoids, saponins, phenolic compounds, and terpenoids, with compounds such as rutin and nicotiflorin reported in high concentrations. These bioactive constituents are associated with various biological activities, including antioxidant, antimicrobial, anti-inflammatory, and antidiabetic effects. Common extraction methods, particularly methanolic Soxhlet extraction, have been shown to effectively isolate these compounds for pharmacological evaluation. Toxicological studies suggest that the saponins present in the leaves are safe for both topical and oral use within recommended limits. Overall, the available evidence indicates that S. mukorossi leaves represent a valuable yet underexplored natural resource with potential applications in medicinal, cosmetic, and nutraceutical fields.

Keywords : Sapindus mukorossi,Phytochemistry,Saponins,Leaf Extract,Antimicrobial Activity ,Antioxidant Activity, Sapindaceae Family.

References :

1. biljana Bauer Petrovska,1Department of Pharmacognosy, Faculty of Pharmacy, SS Cyril and Methodius University, Vodnjanska 17, 1000 Skopje
2. DOCUMENTATION ON SOAP NUT (Sapindus mucorossi) 2006 https://apps.worldagroforestry.org/treedb/AFTPDFS/Sapindus_mukorossi.PDF
3. Orwa C, A Mutua, Kindt R , Jamnadass R, S Anthony. 2009 Agroforestree Database:a tree reference and selection guide version 4.0
4. IJPSR (2011), Vol. 2, Issue 8, B.N. Suhagia, I.S. Rathod, Sunil Sindhu
5. Singh, Reetika Kumari, and Nishi Kumari. "Comparative determination of phytochemicals and antioxidant activity from leaf and fruit of Sapindus mukorrossi Gaertn. – A valuable medicinal tree." Industrial Crops and Products, vol. 73, 2015, pp. 1–8. doi.org
6. Du, M. H., Huang, S. M., Zhang, J. P., Wang, J. W., Hu, L. S., & Jiang, J. M. (2015). Toxicolological Test of Saponins from Sapindus mukorossi Gaerth. Open Journal of Forestry, 5, 749-753. http://dx.doi.org/10.4236/ojf.2015.57067
7. 7.Hosseinzadeh, H., & Nassiri-Asl, M. (2014). Review of the pharmacological effects of Rutin. Iranian Journal of Basic Medical Sciences, 17(7), 493–508.
8. 22. Singh, R., Rai, M.K. & Kumari, N. (2015). Somatic embryogenesis and plant regeneration in Sapindus mukorossi Gaertn. from leaf derived callus induced with 6 benzylaminopurine. Applied Biochemistry and Biotechnology, 177(2), 498 510
9. Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. Journal of Nutritional Science. 2016;5:e47) doi:10.1017/jns.2016.41
10. Xu, Yuanyuan, et al. "Biosynthesis of Plant Triterpenoid Saponins in Microbial Cell Factories." Journal of Agricultural and Food Chemistry, vol. 66, no. 46, 2018, pp. 12155–12165. https://doi.org/10.1021/acs.jafc.8b04657
11. da Silva FMA, da Silva KPA, de Oliveira LPM, Costa EV, Koolen HH, Pinheiro MLB, de Souza AQL, de Souza ADL. Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp). Mem Inst Oswaldo Cruz. 2020 Sep 30;115:e200207. doi: 10.1590/0074-02760200207. PMID: 33027419; PMCID: PMC7534957
12. Journal of Nanjing Forestry University (Natural Sciences Edition), 2021, Vol. 45, No. 4, 83-89 ref. 42 ref.
13. Wei MP, Qiu JD, Li L, Xie YF, Guo YH, Yu H, Cheng YL, Qian H, Yao WR. The chemical profile and biological activity of different extracts of Sapindus mukorossi Gaertn. against Cutibacterium acnes. Nat Prod Res. 2021 Nov;35(22):4740-4745. doi: 10.1080/14786419.2020.1715399. Epub 2020 Jan 29. PMID: 31994913.
14. Sochacki M, Vogt O. Triterpenoid Saponins from Washnut (Sapindus mukorossi Gaertn.)-A Source of Natural Surfactants and Other Active Components. Plants (Basel). 2022 Sep 9;11(18):2355. doi: 10.3390/plants11182355. PMID: 36145756; PMCID: PMC9502486.
15. The International Journal of Progressive Research in Science and Engineering (IJPRSE) Pooja R, Varsha S L, Aliya M S, Chetana Kumar T, Damini B M, Divya H K, Lakshmi J, Sushma J M, Swati K, Annapurneshwari M H, Ravi M, & Vedamurthy A B. (2022).
16. Xu, Y., Zhao, G., Ji, X., Liu, J., Zhao, T., Gao, Y., Gao, S., Hao, Y., Gao, Y., Wang, L., Weng, X., Chen, Z., & Jia, L. (2022). Metabolome and transcriptome analysis reveals the transcriptional regulatory mechanism of triterpenoid saponin biosynthesis in soapberry (Sapindus mukorossi Gaertn.). Journal of Agricultural and Food Chemistry, 70(23), 7095–7109. doi.org
17. Sadeghi M, Miroliaei M, Ghanadian M. Inhibitory effect of flavonoid glycosides on digestive enzymes: In silico, in vitro, and in vivo studies. Int J Biol Macromol. 2022 Sep 30;217:714-730. doi: 10.1016/j.ijbiomac.2022.07.086. Epub 2022 Jul 14. PMID: 35843397
18. Singh, D. K., and Devesh Pratap Singh. "Phytochemistry of Sapindus Mukorossi and Medicinal Properties." Medicinal and Aromatic Plants of the World, 2023, pp. 1-19. EOLSS Publications
19. SAPINDUS MUKOROSSI: A COMPLETE REVIEW ON PHARMACOLOGY, PHYTOCHEMISTRY AND TOXICOLOGICAL DATA Vol. 12 No. 01 (2023): International Journal of AYUSH
20. UPLC-QTOF-ESI-MS/MS-Based Comparative Study of Phytochemicals in Sapindus mukorossi", was published in Horticulturae Volume 11, Issue 6, Article Number 682, in 2025 by authors Neil Patrick Uy, Hak-Dong Lee, Jajung Ku, Kyung Choi, and Sanghyun Lee. The DOI is https://doi.org/10.3390/horticulturae11060682.
21. Journal of Pharmacognosy and Phytochemistry 2025; 14(2): 16-19