Malaria is commonly related with more than
a few stages of reduced blood counts as revealed by
reduced platelets and white cell counts and barely
related with hemorrhagic observations or an aspect of
disseminated intravascular coagulation.
Thrombocytopenia is often seen in falciparum malaria
but the exact mechanism for this is unclear. A large and
thorough search through peer reviewed publications,
conferences, articles and a book was the approach
adopted for the review. This review shows the value of
low platelet count as an early indicator of acute malaria.
The probable mechanism that causes thrombocytopenia
in malaria have been discussed to include; A direct
interaction between plasmodium and platelets, immune
mechanism destruction, destruction of platelets by
spleen under the influence of parasite antigen bound to
the surface, suppression of thrombopoiesis by parasitic
antigen that infiltrate the bone marrow, alteration of
splenic function and oxidative stress. It was found out
that reduced platelet be counted which tiers from slight
to average is a frequent affiliation of the Plasmodium
falciparum infection thereby predicting its severity.