Authors :
Sankara Narayanan Ravi
Volume/Issue :
Volume 10 - 2025, Issue 5 - May
Google Scholar :
https://tinyurl.com/44cxe7c7
DOI :
https://doi.org/10.38124/ijisrt/25may2166
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
The human hearts limited regenerative potential, due to the absence of endogenous stem cells and terminal
differentiation of cardiomyocytes, poses a challenge for conventional tissue engineering. Three-dimensional (3D) printing
and bio-printing have emerged as transformative technologies in cardiovascular medicine, enabling the development of
patient=specific anatomical models and bioengineered implants for therapeutic applications. This review examines over
many studies, highlighting the innovations in 3D cardiovascular modelling, tissue engineering, and the integration of stem
cell-derived bio-inks. High resolution imaging modalities like CT, MRI and echocardiography facilitate precise anatomical
reconstruction, while bio-printing advances the fabrication of functional myocardial tissues, vascular grafts, and autologous
heart valves. These developments address key limitations of conventional prosthetics, including immune rejection, poor
biocompatibility, and the need for long term anticoagulation. However, challenge persist in replicating complex cardiac
vascularisation and ensuring long term viability of bio printed constructs. Overall, 3D bio-printing holds substantial promise
for personalised cardiovascular interventions, with ongoing advancements in cellular integrating, material science, and
imaging poised to enhance its clinical translation.
References :
- Bliley JM, Stang MA, Behre A, Feinberg AW. Advances in 3d bioprinted cardiac tissue using stem cell-derived cardiomyocytes. Stem Cells Translational Medicine. 2024 May 1;13(5):425-35. DOI: 10.1093/stcltm/szae014
- Prakash A, Sridhar SB, Wali AF, Talath S, Shareef J, Malviya R. 3D and 4D Printed Materials for Cardiac Transplantation: Advances in Biogenerative Engineering. Bioprinting. 2024 Oct 12: e00362. DOI: 10.1016/j.bprint. 2024.e00362
- Wang Z, Wang L, Li T, Liu S, Guo B, Huang W, Wu Y. 3D bioprinting in cardiac tissue engineering. Theranostics. 2021 Jul 6;11(16):7948. DOI: 10.7150/thno.61621
- Ballard DH, Trace AP, Ali S, Hodgdon T, Zygmont ME, DeBenedectis CM, Smith SE, Richardson ML, Patel MJ, Decker SJ, Lenchik L. Clinical applications of 3D printing: primer for radiologists. Academic radiology. 2018 Jan 1;25(1):52-65.
The human hearts limited regenerative potential, due to the absence of endogenous stem cells and terminal
differentiation of cardiomyocytes, poses a challenge for conventional tissue engineering. Three-dimensional (3D) printing
and bio-printing have emerged as transformative technologies in cardiovascular medicine, enabling the development of
patient=specific anatomical models and bioengineered implants for therapeutic applications. This review examines over
many studies, highlighting the innovations in 3D cardiovascular modelling, tissue engineering, and the integration of stem
cell-derived bio-inks. High resolution imaging modalities like CT, MRI and echocardiography facilitate precise anatomical
reconstruction, while bio-printing advances the fabrication of functional myocardial tissues, vascular grafts, and autologous
heart valves. These developments address key limitations of conventional prosthetics, including immune rejection, poor
biocompatibility, and the need for long term anticoagulation. However, challenge persist in replicating complex cardiac
vascularisation and ensuring long term viability of bio printed constructs. Overall, 3D bio-printing holds substantial promise
for personalised cardiovascular interventions, with ongoing advancements in cellular integrating, material science, and
imaging poised to enhance its clinical translation.
