Authors :
Belsarkar AS; Shinde AD; Adsul PS; Dhokale VB.
Volume/Issue :
Volume 7 - 2022, Issue 8 - August
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3ARW79a
DOI :
https://doi.org/10.5281/zenodo.7027118
Abstract :
- Epilepsy, trigeminal neuralgia, and bipolar
disorder are just a few of the conditions that are treated
with Carbamazepine, a Dibenzazepine derivative. Firstline treatment for seizures that has exceptional efficacy
and is inexpensive is Carbamazepine (CBZ). Due to their
high membrane permeability and low water solubility,
which make dissolution the rate-limiting step in the
absorption process, they are categorised as BCS class II
substances by the Biopharmaceutical Classification
System. The polymorphic alterations of the drug
Carbamazepine are examined in its tablet dosage form by
taking into consideration variations in the granulation
process or method. To discover the polymorphic
alterations in Carbamazepine, a DSC study was
conducted for a tablet formulation. This study is set out to
investigation to identify the effects of various granulation
techniques on the drug Carbamazepine for distinct
polymorphic alterations in tablet dosage form.
Keywords :
Carbamazepine, Polymorphism, DSC, Variations, Epilepsy, Tablet.
- Epilepsy, trigeminal neuralgia, and bipolar
disorder are just a few of the conditions that are treated
with Carbamazepine, a Dibenzazepine derivative. Firstline treatment for seizures that has exceptional efficacy
and is inexpensive is Carbamazepine (CBZ). Due to their
high membrane permeability and low water solubility,
which make dissolution the rate-limiting step in the
absorption process, they are categorised as BCS class II
substances by the Biopharmaceutical Classification
System. The polymorphic alterations of the drug
Carbamazepine are examined in its tablet dosage form by
taking into consideration variations in the granulation
process or method. To discover the polymorphic
alterations in Carbamazepine, a DSC study was
conducted for a tablet formulation. This study is set out to
investigation to identify the effects of various granulation
techniques on the drug Carbamazepine for distinct
polymorphic alterations in tablet dosage form.
Keywords :
Carbamazepine, Polymorphism, DSC, Variations, Epilepsy, Tablet.
