Authors :
Sri Rahmadhona; Asmin Lubis; Dadik Wahyu Wijaya; Akhyar Hamonangan Nasution
Volume/Issue :
Volume 5 - 2020, Issue 8 - August
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/2R2q52x
DOI :
10.38124/IJISRT20AUG314
Abstract :
Acute Kidney Injury (AKI) is a common
complication in patients with critical illness or multiple
comorbid conditions who are hospitalized, especially at
the Intensive Care Unit (ICU). AKI is associated with
increased in short and long term mortality and
morbidity. The connection between MAP and CVP on
alteration of AKI causes researcher interested to
investigate the correlation between Mean Perfusion
Pressure (MPP) as a difference between MAP and CVP
on the progression of AKI.
Methods:
Forty-two patients treated in the ICU who met
inclusion criteria (ages 18-65 years and signed informed
consent) and exclusion criteria (chronic kidney disease,
refused to have Central Venous Catheters (CVC)
installed, and heart disease). After CVC installation, we
perform hemodynamic examination, MAP and CVP
measurements, and serum creatinine examination after
installation, 6 hours, 12 hours, and 48 hours after
installation.
Results:
Significant differences were obtained during 12-
hour observation between MPP values in the AKI group
with lower values than the non-AKI group (p=0.009)
and also obtained a significant difference during 48-
hours observation between MPP values in the AKI
group with a lower value than the non-AKI group
(p=0.001). MAP values showed a significant difference
at 12-hour observation time with creatinine serum in
the MAP group<65mmHg higher than the
MAP 65mmHg group (p=0.035). MPP values showed
significant differences 12-hours observation with
creatinine serum in the MPP group<55mmHg was
higher than the MPP group 55mmHg (p=0.044). In
addition, there was a correlation between creatinine
serum increase with MPP decrease (r=-0.476; p=0.001).
Conclusion:
Lower MPP tend to increase AKI occurence
contrary higher MPP decrease AKI occurence at the
observation. The mean MPP of AKI group was 90.6
( 24.2) mmHg at T0, 78.2 ( 22.6) mmHg at T1, 67.2
( 20.9) mmHg at T3, and 57, 0 ( 20,2) mmHg at T4
observation.
Keywords :
AKI, ICU, MAP, CVP, MPP, CVC
Acute Kidney Injury (AKI) is a common
complication in patients with critical illness or multiple
comorbid conditions who are hospitalized, especially at
the Intensive Care Unit (ICU). AKI is associated with
increased in short and long term mortality and
morbidity. The connection between MAP and CVP on
alteration of AKI causes researcher interested to
investigate the correlation between Mean Perfusion
Pressure (MPP) as a difference between MAP and CVP
on the progression of AKI.
Methods:
Forty-two patients treated in the ICU who met
inclusion criteria (ages 18-65 years and signed informed
consent) and exclusion criteria (chronic kidney disease,
refused to have Central Venous Catheters (CVC)
installed, and heart disease). After CVC installation, we
perform hemodynamic examination, MAP and CVP
measurements, and serum creatinine examination after
installation, 6 hours, 12 hours, and 48 hours after
installation.
Results:
Significant differences were obtained during 12-
hour observation between MPP values in the AKI group
with lower values than the non-AKI group (p=0.009)
and also obtained a significant difference during 48-
hours observation between MPP values in the AKI
group with a lower value than the non-AKI group
(p=0.001). MAP values showed a significant difference
at 12-hour observation time with creatinine serum in
the MAP group<65mmHg higher than the
MAP 65mmHg group (p=0.035). MPP values showed
significant differences 12-hours observation with
creatinine serum in the MPP group<55mmHg was
higher than the MPP group 55mmHg (p=0.044). In
addition, there was a correlation between creatinine
serum increase with MPP decrease (r=-0.476; p=0.001).
Conclusion:
Lower MPP tend to increase AKI occurence
contrary higher MPP decrease AKI occurence at the
observation. The mean MPP of AKI group was 90.6
( 24.2) mmHg at T0, 78.2 ( 22.6) mmHg at T1, 67.2
( 20.9) mmHg at T3, and 57, 0 ( 20,2) mmHg at T4
observation.
Keywords :
AKI, ICU, MAP, CVP, MPP, CVC
