 Background Therapeutic communication plays a very important role in nursing services, because therapeutic communication is an absolute activity and determines the relationship or interaction of nurses and patients in supporting the recovery of patients and finding solutions to problems that are being experienced by clients. Purpose: This study aims to determine the relationship of knowledge factors with the application of therapeutic communication by implementing nurses in the inpatient room of Eraldi Bahar Hospital Palembang in 2018. Methods and samples: This study was descriptive with quantitative methods. The sampling technique is the Total Sampling method. The number of samples was 52 people from 5 inpatient rooms of Ernaldi Bahar Hospital Palembang for 11 months from June 2017 to May 2018. Results: Based on the results of the study it was found that out of 52 nurses, 44.2% were aged 36-40 years, 78.8% were female, 36.5% had vocational education, 65.4% had good knowledge of therapeutic communication. The results of bivariate analysis found that there was a relationship between knowledge factors and the application of therapeutic communication p value = 0.008. Conclusion: There is a relationship between the knowledge factor and the application of therapeutic communication at Ernaldi Hospital. Suggestion: Hospitals can increase the knowledge of nurses in the inpatient room specifically about therapeutic communication by conducting conference and training for implementing nurses.

Keywords : Nurse, Therapeutic Communication, Knowledge.