Authors :
Mohamed Belcaid; Nabil Gaougaou; Oussama Aazzane; Abderahman Mellouki; Fatima Zahra Bakhtaoui; Saida Stitou; Mehdi Karkouri
Volume/Issue :
Volume 8 - 2023, Issue 10 - October
Google Scholar :
https://tinyurl.com/5czuuzjv
Scribd :
https://tinyurl.com/hyzz2y3m
DOI :
https://doi.org/10.5281/zenodo.10047340
Abstract :
Introduction:
Bronchopulmonary cancers (CBP) represent the
leading cause of death in men worldwide. In this study,
we present the epidemiological, histopathological, and
immunohistochemical characteristics of CBP diagnosed
in Moroccan lung cancer patients.Methods:
We conducted a cross-sectional study during the
year 2018. We used a data sheet for collecting clinical,
histological, and immunohistochemical data of CBP
patients. Descriptive statistical analysis was performed
to determine frequencies and percentages. Bivariate
analysis was used to examine the association between the
dependent variable (histological type) and independent
variables (age and gender).Results:
In 2018, we analyzed the anatomopathological
reports of 246 CBP patients, with an average age of 61.3
years and a gender ratio of 2.72. Adenocarcinomas
(ADC) were the most common, accounting for 54.5% of
cases. The TNM classification of operated cases showed
that tumor sizes T2, T3, and T4 represented 20%, 57%,
and 23%, with N0 at 40%, N1 at 33%, and N2 at 27%.
Secondary tumors accounted for 10% of cases, with 46%
originating from the breast. Immunohistochemically,
TTF-1 expression was found in 89% of ADC cases, anti-
p63 antibody expression was positive in 100% of
squamous cell carcinoma cases. For neuroendocrine
carcinoma cases, synaptophysin expression and
chromogranin A had positivity rates of 100% and 60%,
respectively. Bivariate analysis did not show any
significant association between histological types and age
or gender.Conclusion:
We concluded that this series allows for the analysis
of the profile of CBP cases diagnosed in a major lung
cancer treatment center in Morocco. The predominance
of adenocarcinoma tumors in the profile should caution
against hasty conclusions, with the systematic testing of
TTF-1 and anatomoclinical correlation before
determining the primary tumor. Diagnosis remains
delayed in our context due to the advanced stages that
continue to prevail.
Keywords :
Bronchopulmonary Cancer, Epidemiology, Histopathology, Immunohistochemistry.
Introduction:
Bronchopulmonary cancers (CBP) represent the
leading cause of death in men worldwide. In this study,
we present the epidemiological, histopathological, and
immunohistochemical characteristics of CBP diagnosed
in Moroccan lung cancer patients.Methods:
We conducted a cross-sectional study during the
year 2018. We used a data sheet for collecting clinical,
histological, and immunohistochemical data of CBP
patients. Descriptive statistical analysis was performed
to determine frequencies and percentages. Bivariate
analysis was used to examine the association between the
dependent variable (histological type) and independent
variables (age and gender).Results:
In 2018, we analyzed the anatomopathological
reports of 246 CBP patients, with an average age of 61.3
years and a gender ratio of 2.72. Adenocarcinomas
(ADC) were the most common, accounting for 54.5% of
cases. The TNM classification of operated cases showed
that tumor sizes T2, T3, and T4 represented 20%, 57%,
and 23%, with N0 at 40%, N1 at 33%, and N2 at 27%.
Secondary tumors accounted for 10% of cases, with 46%
originating from the breast. Immunohistochemically,
TTF-1 expression was found in 89% of ADC cases, anti-
p63 antibody expression was positive in 100% of
squamous cell carcinoma cases. For neuroendocrine
carcinoma cases, synaptophysin expression and
chromogranin A had positivity rates of 100% and 60%,
respectively. Bivariate analysis did not show any
significant association between histological types and age
or gender.Conclusion:
We concluded that this series allows for the analysis
of the profile of CBP cases diagnosed in a major lung
cancer treatment center in Morocco. The predominance
of adenocarcinoma tumors in the profile should caution
against hasty conclusions, with the systematic testing of
TTF-1 and anatomoclinical correlation before
determining the primary tumor. Diagnosis remains
delayed in our context due to the advanced stages that
continue to prevail.
Keywords :
Bronchopulmonary Cancer, Epidemiology, Histopathology, Immunohistochemistry.
