Authors : Dr. Seema Jacob; Shrutika Sharma; Bharat Legha; Chhavi Jain; Vikas Kumar; Satish Jasnathi

Volume/Issue : Volume 8 - 2023, Issue 12 - December

Google Scholar : http://tinyurl.com/yc8y6ds6

Scribd : http://tinyurl.com/mryc9vk7

DOI : https://doi.org/10.5281/zenodo.10417020

Abstract : Cimetidine, a widely used histamine H2 receptor antagonist, has shown potential teratogenic effects in animal models. This study aimed to investigate the behavioral teratogenic impact of cimetidine on the offspring of albino rats. Pregnant albino rats were exposed to varying doses of cimetidine during specific gestational periods. Postnatally, the behavior of the offspring was assessed using standardized behavioral tests, including maze trials and social interaction assessments. Statistical analyses revealed significant alterations in the behavioral patterns of the cimetidine- exposed offspring compared to control groups. Findings suggest notable differences in exploratory behavior, anxiety levels, and social interactions among the exposed offspring. These observed alterations provide evidence supporting the hypothesis that prenatal exposure to cimetidine induces behavioral changes in the offspring. The results underscore the importance of further research to delineate the mechanisms underlying cimetidine's teratogenic effects and its implications for prenatal exposure on behavioral outcomes. Understanding these effects is crucial for informing clinical practices and maternal healthcare guidelines.

Keywords : Teratogenicity, Cimetidine, Albino Rats, Prenatal Exposure, Behavioral Effects, Offspring Development, Histamine H2 Receptor Antagonist, Maternal Drug Exposure.