As we witness the evolution of technology day by day and how it revolutionizes all the applied fields too. In this review article we will know about how advancement in technology affected the way we procure vaccines, how we found a more convenient method and how it has been used and achieved results. What led to the discovery of Reverse vaccinology? The approach it uses for determining potential vaccine candidates and tools that have been developed to ease one’s research and how the approach is different from that of the conventional method.