Authors :
Albert; Akhyar Hamonangan Nasution; Qadri Fauzi Tanjung
Volume/Issue :
Volume 5 - 2020, Issue 8 - August
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/2Ru1DHy
DOI :
10.38124/IJISRT20AUG376
Abstract :
Spinal anesthesia was typically used for elective
surgery and was associated with the incidence of
hypotension and bradycardia due to sympathetic block.
Bezold-Jarisch reflex (BJR) is a reflex that contributes
to cause hypotension and bradycardia mediated by
serotonin receptors (5-HT3). Ondansetron, a 5-HT3
receptor antagonist, is assumed to inhibit the effect of
serotonin and BJR.
To assess the effectiveness of ondansetron in
preventing hypotension and bradycardia after spinal
anesthesia.
This study was an experimental study with a
"posttest with control group" design conducted at Haji
Adam Malik General Hospital and USU Hospital in
February 2020 to June 2020. Seventy study subjects
who underwent lower abdominal, gynecology, lower
extremities under spinal anesthesia were selected by
consecutive sampling and were divided into 2 groups.
Group 1 received 4 mg ondansetron, while group 2
received 2 cc normal saline, both interventions were
given 30 minutes before spinal anesthesia
Baseline and minimum mean arterial pressure
were higher in the ondansetron group at 97.07 ± 5.09
mmHg and 85.20 ± 6.48 mmHg compared to the control
group (p-value <0.05). Hypotension was more common
in the control group (51.43%) than in ondansetron
group (20%) (p-value <0.05). The mean baseline and
minimum heart rate were higher in the ondansetron
group at 81,09 ± 9,62 bpm and 79.7 ± 8.75 bpm
compared to the control group (p<0.05). The incidence
of bradycardia was more common in the control group
(17.1%) compared to the ondansetron group (2.9%) (pvalue <0.05).
Ondansetron 4 mg, given intravenously, is effective
in lowering the incidence of hypotension and
bradycardia under spinal anesthesia
Keywords :
Ondansetron, Hypotension, Bradycardia, Spinal Anesthesia
Spinal anesthesia was typically used for elective
surgery and was associated with the incidence of
hypotension and bradycardia due to sympathetic block.
Bezold-Jarisch reflex (BJR) is a reflex that contributes
to cause hypotension and bradycardia mediated by
serotonin receptors (5-HT3). Ondansetron, a 5-HT3
receptor antagonist, is assumed to inhibit the effect of
serotonin and BJR.
To assess the effectiveness of ondansetron in
preventing hypotension and bradycardia after spinal
anesthesia.
This study was an experimental study with a
"posttest with control group" design conducted at Haji
Adam Malik General Hospital and USU Hospital in
February 2020 to June 2020. Seventy study subjects
who underwent lower abdominal, gynecology, lower
extremities under spinal anesthesia were selected by
consecutive sampling and were divided into 2 groups.
Group 1 received 4 mg ondansetron, while group 2
received 2 cc normal saline, both interventions were
given 30 minutes before spinal anesthesia
Baseline and minimum mean arterial pressure
were higher in the ondansetron group at 97.07 ± 5.09
mmHg and 85.20 ± 6.48 mmHg compared to the control
group (p-value <0.05). Hypotension was more common
in the control group (51.43%) than in ondansetron
group (20%) (p-value <0.05). The mean baseline and
minimum heart rate were higher in the ondansetron
group at 81,09 ± 9,62 bpm and 79.7 ± 8.75 bpm
compared to the control group (p<0.05). The incidence
of bradycardia was more common in the control group
(17.1%) compared to the ondansetron group (2.9%) (pvalue <0.05).
Ondansetron 4 mg, given intravenously, is effective
in lowering the incidence of hypotension and
bradycardia under spinal anesthesia
Keywords :
Ondansetron, Hypotension, Bradycardia, Spinal Anesthesia
