one of the problems with exclusive breastfeeding is inadequate breast milk production. Therefore, the solution is with papaya leaves as lactogogue. Lactogogue can increase the secretion and production of breast milk. The management of papaya leaves at the nanoparticle level can increase drug absorption by the body. This research aims to determine the effect of nanoparticle supplementation from papaya leaves to increase the weight of babies. This increasing weight becomes an indicator of breast milk production. This true experimental research used a randomized pretest-posttest design with the control group. The researchers used 36 postpartum mothers as respondents. The respondents were grouped into intervention and control groups. The intervention group received a nanoparticle capsule from papaya leaves with 458mg/day for seven days. During this administration, the intervention group also received standard postpartum care. The control group received placebo and standard postpartum care. The researchers measured babies' weight before and after the treatment for eight days with a digital weigher. Then, the researchers tested the data statistically with paired T-test. The findings showed a score of p < 0.001. It indicated differences in babies' weights from intervention and control groups. Thus, consuming nanoparticle capsules from papaya leaves, dose 458 mg/day for seven days, could increase the weight of the babies

Keywords : Nanoparticles, Papaya leaves, Breast milk production, Papaya leave capsule