This study took for comparing efficacy of IV Dexmedetomidine 0.5µg/kg and IV Dexmedetomidine 1µg /kg in obtunding the hemodynamic response to laryngoscopy and endotracheal intubation when administered 10 minutes before induction. Methodology: A Ninety patients scheduled for various elective and emergency surgical procedures under general anesthesia belonging to ASA class I & II and Mallampati grade I & II in the age group of 18 years to 60 years were included in the study. The study population was randomly divided into three groups group A received normal saline and represent as control , group B received IV Dexmedetomidine in a dose of 0.5µg/kg, group C received IV Dexmedetomidine in a dose of 1µg/kg The HR, SBP, DBP and MAP were recorded at the following intervals, namely, basal reading before giving the study drug, at 5 minute intervals from the end of drug infusion until induction, post induction/ prelaryngoscopy and at 1, 2.5, 5, 10, 15 and 20 minutes following tracheal intubation.

Keywords : Dexmedetomidine, Hemodynamic Response.