Authors : H K Sacheat; A A Esaa; F S Abdulhadi

Volume/Issue : Volume 9 - 2024, Issue 8 - August

Google Scholar : https://tinyurl.com/hcz2kxbm

Scribd : https://tinyurl.com/ym476upf

DOI : https://doi.org/10.38124/ijisrt/IJISRT24AUG956

Abstract : Helicobacter pylori (H. pylori) is a dangerous bacteria that is known to colonize the abdominal mucosa in humans. Infection with H. pylori is enormously conventional worldwide; the micro organism influences up to 90% of grownup populations in creating countries. Besides gastric problems, severa latest investigations have confirmed the correlation between H. pylori infection and different illnesses like hematologic, ophthalmologic, dermatologic, neurologic, and hepatobiliary. According to some indicators, the liver is one of the organs may additionally also be affected with the aid of H. pylori; however, it is but unknown how exactly the contamination impacts the liver and the underlying mechanisms are unclear. The effects was once fantastically enormous lver features in serum of patient groups (P) in contrast to control group (C) (p<0.001), Meanwhile, there had been no giant differences located between male and girl in all studies groups. And Urea Breath Test in Breath in all groups is presented. Patients' groups shows highly significant increase when compared to control group (p<0.001).

Keywords : Liver Function; Helicobacter pylori; GOT, GPT, TSB.

References :

1. Kalali, B., L. Formichella, and M. Gerhard, Diagnosis of Helicobacter pylori: Changes towards the Future. Diseases, 2015. 3(3): p. 122-135.
2. Wang, Y.-K., et al., Diagnosis of Helicobacter pylori infection: Current options and developments. World Journal of Gastroenterology: WJG, 2015. 21(40): p. 112-21.
3. Hooi, J.K., et al., Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology, 2017. 153(2): p. 420-429.
4. Warren, J.R. and B. Marshall, Unidentified curved bacilli on gastric epithelium in active chronic gastritis. The lancet, 1983. 321(8336): p. 1273-1275.
5. Chey, W.D., G.I. Leontiadis, C.W. Howden, and S.F. Moss, ACG clinical guideline: treatment of Helicobacter pylori infection. Official journal of the American College of Gastroenterology| ACG, 2017. 112(2): p. 212-239.
6. Delvin, E.E., et al., Accuracy of the [13C]-urea breath test in diagnosing Helicobacter pylori gastritis in pediatric patients. Journal of pediatric gastroenterology and nutrition, 1999. 28(1): p. 59-62.
7. Lopes, A.I., F.F. Vale, and M. Oleastro, Helicobacter pylori infection-recent developments in diagnosis. World journal of gastroenterology: WJG, 2014. 20(28): p. 9299.
8. Sabbagh, P., et al., Diagnostic methods for Helicobacter pylori infection: ideals, options, and limitations. European Journal of Clinical Microbiology & Infectious Diseases, 2019. 38: p. 55-66.
9. Best, L.M., et al., Non‐invasive diagnostic tests for Helicobacter pylori infection. Cochrane Database of Systematic Reviews, 2018(3).p.23-51.
10. Sankararaman, S. and L. Moosavi, Urea breath test, in StatPearls [Internet]. 2021, StatPearls Publishing.
11. Patel, S.K., et al., Diagnosis of Helicobacter pylori: what should be the gold standard? World journal of gastroenterology: WJG, 2014. 20(36): p. 12847.
12. Osaki, T., K. Mabe, T. Hanawa, and S. Kamiya, Urease-positive bacteria in the stomach induce a false-positive reaction in a urea breath test for diagnosis of Helicobacter pylori infection. Journal of medical microbiology, 2008. 57(7): p. 814-819.
13. Borriello, S., et al., Microbial and metabolic profile of achlorhydric stomach: comparison of pernicious anaemia and hypogammaglobulinaemia. Journal of clinical pathology, 1985. 38(8): p. 946-953.
14. Savarino, V., S. Vigneri, and G. Celle, The 13C urea breath test in the diagnosis ofHelicobacter pylori infection. Gut, 1999. 45(suppl 1): p. I18-I22.
15. Ferwana, M., et al., Accuracy of urea breath test in Helicobacter pylori infection: meta-analysis. World journal of gastroenterology: WJG, 2015. 21(4): p. 1305.
16. Leal, Y.A., et al., 13C‐urea breath test for the diagnosis of Helicobacter pylori infection in children: a systematic review and meta‐analysis. Helicobacter, 2011. 16(4): p. 327-337.
17. Doulberis, M., et al., Active Helicobacter pylori infection is independently associated with nonalcoholic steatohepatitis in morbidly obese patients. Journal of clinical medicine, 2020. 9(4): p. 933.
18. Hata, K., et al. Assessing the relationship between Helicobacter pylori and chronic kidney disease. in Healthcare. 2021. MDPI.
19. Lupu, A., et al., The prevalence of liver cytolysis in children with helicobacter pylori infection. Children, 2022. 9(10): p. 1498.
20. Kumar, J.B., B.M. Goud, and A. Kumar, Liver Function Tests: Biochemical Overview for Clinical Correlation. hormones, 2021. 25: p. 26.
21. Kalwar, H.A., et al. Prevalence of common bile duct stones on endoscopic retrograde cholangiopancreatography in gallstone pancreatitis with deranged liver function. in Med Forum. 2020.
22. Finteil, S.A., A.S. Jabbar, and Q.I.A. Majeed, Study of the impact of some liver enzymes (GOT, GPT, ALP) for the employees at the Tuwaitha nuclear site. Journal of Madenat Alelem University College, 2019. 11(1): p. 10-18.
23. Bolognese, M.A., et al., Terapia nutricional domiciliar: uma revisão. Research, Society and Development, 2022. 11(3): p. e34011326130-e34011326130.
24. Fox, J., et al., Helicobacter bilis sp. nov., a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice. Journal of clinical microbiology, 1995. 33(2): p. 445-454.
25. Franklin, C.L., et al., Isolation of a novel Helicobacter species, Helicobacter cholecystus sp. nov., from the gallbladders of Syrian hamsters with cholangiofibrosis and centrilobular pancreatitis. Journal of clinical microbiology, 1996. 34(12): p. 2952-2958.
26. Kawaguchi, M., et al., Bacteria closely resembling Helicobacter pylori detected immunohistologically and genetically in resected gallbladder mucosa. Journal of gastroenterology, 1996. 31: p. 294-298.
27. Nilsson, H.-O., et al., Identification of Helicobacter pylori and other Helicobacter species by PCR, hybridization, and partial DNA sequencing in human liver samples from patients with primary sclerosing cholangitis or primary biliary cirrhosis. Journal of clinical microbiology, 2000. 38(3): p. 1072-1076.
28. Rabelo-Gonçalves, E.M., B.M. Roesler, and J.M. Zeitune, Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World journal of hepatology, 2015. 7(30): p. 2968.
29. Dogan, Z., et al., Association between Helicobacter pylori and liver-to-spleen ratio: a randomized-controlled single-blind study. European Journal of Gastroenterology & Hepatology, 2013. 25(1): p. 107-110.
30. Pellicano, R., et al., Helicobacter pyloriiseroprevalence in hepatitis C virus positive patients with cirrhosis. Journal of hepatology, 2000. 33(4): p. 648-650.
31. Xuan, S.-Y., et al., Helicobacter infection in hepatocellular carcinoma tissue. World Journal of Gastroenterology: WJG, 2006. 12(15): p. 2335.
32. Akbas, H.S., et al., The assessment of carotid intima media thickness and serum paraoxonase-1 activity in Helicobacter pylori positive subjects. Lipids in health and disease, 2010. 9(1): p. 1-6.
33. Salehi, H., et al., The effect of Helicobacter pylori eradication on liver enzymes in patients referring with unexplained hypertransaminasemia. Advanced biomedical research, 2014. 3.