Teratogenic Effect of Different Drugs at Different Stages in Pregnancy


Authors : Ambeya khatoon; Rohit Kumar Trivedi (Guide)

Volume/Issue : Volume 8 - 2023, Issue 6 - June

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/7efsjwwd

DOI : https://doi.org/10.5281/zenodo.8126293

Abstract : Because of the potential for teratogenic medication effects on the foetus, treating common ailments during pregnancy is challenging. The first eight weeks of human development are referred to as the embryogenesis period, sometimes known as the organogenesis period. Such a deficiency is caused by a teratogenic agent, which are compounds that could harm the human embryo or foetus physically or functionally. An acknowledgment of the tragedies caused by the thalidomide epidemic in the 1970s and the rubella epidemic in the early 1960s in the field of teratology. Chloramphenicol, Warfarin, Valproate, and Thalidomide are a few of the medications that might cause abnormalities such microcephaly, hydrocephalus, spina bifida, and a number of other syndromes. Many of these substances can enter human tissue and a developing foetus, which can have detrimental effects on the human reproductive health. Numerous biological and physical elements, like as radiation and infection, contribute to teratogenic effects.

Keywords : Teratogenic, Teratogenicity, Birth Defects, Pregnancy, Early Pregnancy, Miscarriage, Stillbirth, Preterm Birth, Congenital abnormalities.

Because of the potential for teratogenic medication effects on the foetus, treating common ailments during pregnancy is challenging. The first eight weeks of human development are referred to as the embryogenesis period, sometimes known as the organogenesis period. Such a deficiency is caused by a teratogenic agent, which are compounds that could harm the human embryo or foetus physically or functionally. An acknowledgment of the tragedies caused by the thalidomide epidemic in the 1970s and the rubella epidemic in the early 1960s in the field of teratology. Chloramphenicol, Warfarin, Valproate, and Thalidomide are a few of the medications that might cause abnormalities such microcephaly, hydrocephalus, spina bifida, and a number of other syndromes. Many of these substances can enter human tissue and a developing foetus, which can have detrimental effects on the human reproductive health. Numerous biological and physical elements, like as radiation and infection, contribute to teratogenic effects.

Keywords : Teratogenic, Teratogenicity, Birth Defects, Pregnancy, Early Pregnancy, Miscarriage, Stillbirth, Preterm Birth, Congenital abnormalities.

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