Authors :
Sourabh N Chiplunkar; Harsharaj K
Volume/Issue :
Volume 9 - 2024, Issue 7 - July
Google Scholar :
https://tinyurl.com/44n3zjcr
Scribd :
https://tinyurl.com/s49bwrwr
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24JUL972
Abstract :
Case: A 47 year old male, came with history of
bilateral hip pain ,insidious in onset gradually
progressive, with difficulty in walking unassisted since 2
years. No history of fall/ trauma. Patient is known case of
retroviral disease and on ART (TLE regimen ) since 2
years. Relevant radiographs were done and was
diagnosed with bilateral neck of femur stress fracture
(Tenofovir induced) associated with hypophosphatemia.
ART regimen was changed to (Abacavir ,Lamivudine ,
Dolutegravir) . Patient on regular follow up every 2
months with serial radiographs. . On 6 months follow up
patient is symptomatically improved with healing
bilateral neck of femur stress fracture.
Keywords :
Tenofovir, Stress Fracture , ART.
References :
- Atypical femoral neck stress fracture in a human immunodeficiency virus-infected patient despite anti-osteoporotic treatment: A case report Rana Terlemez1 , Mehmet Mesut Sönmez2 , Aziz Ahmad Hamidi, Figen Yılmaz
- Looker AC, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP, et al. Updated data on proximal femur bone mineral levels of US adults Osteoporos Int 1998 8 468 89
- Tebas P, Powderly WG, Claxton S, Marin D, Tantisiriwat W, Teitelbaum SL, et al. Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy AIDS 2000 14 F63 7
- Triant VA, Brown TT, Lee H, Grinspoon SK Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system J Clin Endocrinol Metab 2008 93 3499 504
- Womack JA, Goulet JL, Gibert C, Brandt C, Chang CC, Gulanski B, et al. Increased risk of fragility fractures among HIV infected compared to uninfected male veterans PLoS One 2011 6 e17217
- McDermott AY, Terrin N, Wanke C, Skinner S, Tchetgen E, Shevitz AH CD4+cell count, viral load, and highly active antiretroviral therapy use are independent predictors of body composition alterations in HIV-infected adults: A longitudinal study Clin Infect Dis 2005 41 1662 70
- Brown TT, Mallon PW. Editorial: Working towards an understanding of bone disease in HIV. Curr Opin HIV AIDS. 2016;11:251–252.
- de Menezes EG, Machado AA, Barbosa F Jr, de Paula FJ, Navarro AM. Bone metabolism dysfunction mediated by the increase of proinflammatory cytokines in chronic HIV infection. J Bone Miner Metab. 2017;35:234–242.
Case: A 47 year old male, came with history of
bilateral hip pain ,insidious in onset gradually
progressive, with difficulty in walking unassisted since 2
years. No history of fall/ trauma. Patient is known case of
retroviral disease and on ART (TLE regimen ) since 2
years. Relevant radiographs were done and was
diagnosed with bilateral neck of femur stress fracture
(Tenofovir induced) associated with hypophosphatemia.
ART regimen was changed to (Abacavir ,Lamivudine ,
Dolutegravir) . Patient on regular follow up every 2
months with serial radiographs. . On 6 months follow up
patient is symptomatically improved with healing
bilateral neck of femur stress fracture.
Keywords :
Tenofovir, Stress Fracture , ART.