The present comparative cross sectional study was planned to compare cytokine levels in the tear of patients with acute allergic conjunctivitis ( AAC), choronic allergic conjunctivitis ( CAC) and healthy population. Subjects were divided into Group 1 (without allergic conjunctivitis), Group 2 ( with AAC), and Group 3 (with CAC). Tears were collected using Schirmer strips and cytokine analysis &IgE analysis was performed using enzyme linked immune sorbent assay and by fully auto analyser. There were a total of 149 subjects. Cytokine ( IL-2,4,5,8) levels & eosinophil count in the group with acute allergic conjunctivitis were approximately two to five -fold higher than in the group with healthy control group where the cytokines,

Keywords : Cytokine, Eosinophil, IgE, Acute allergic conjunctivitis, Chronic allergic conjunctivitis.