Internal root resorption is associated with progressive destruction of intraradicular dentin due to the activation of clastic cells. The treatment requires elimination of the causative factors and repair of the resorptive defect with biocompatible materials. Calcium hydroxide intracanal medicament, sodium hypochlorite irrigation and MTA are effective adjuvants in managing root resorptive defects. Endodontic management of resorption requires specific modifications in cleaning, shaping and obturation techniques.

Keywords : Internal Root Resorption, MTA, OPG/RANKL/RANK Transcription Factor, Clastic Cells.