Systemic Lupus Erythematosus and HenochSchönlein Purpura

Authors : Jaouad Yousfi; Amal Elouakhoumi; Mouna Zahlane; Lamiaa Essaadouni

Volume/Issue : Volume 6 - 2021, Issue 4 - April

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Systemic lupus erythematosus (SLE) is an autoimmune disease that can cause kidney damage. However, lupus-unrelated renal injury has rarely been described in patients with SLE. We report the observation of a 28-year-old woman presenting with vascular purpura, inflammatory joint pain and abdominal pain. The skin biopsy showed vasculitis while direct immunofluorescence demonstrated IgA deposits. Two months later, the patient presented with malar rash and lower limb edema. She tested positive for antinuclear antibodies (1/1280 with a homogeneous pattern) and for anti-dsDNA (300 IU). Proteinuria was at 4.18g/24h. Renal biopsy revealed proliferative glomerulonephritis with IgA deposits. The diagnosis of SLE and IgA vasculitis with renal involvement was established. The patient was treated with corticosteroids and cyclophosphamide.

Keywords : Systemic Lupus Erythematosus -IgA Vasculitis – Nephropathy


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