Authors :
Jaouad Yousfi; Amal Elouakhoumi; Mouna Zahlane; Lamiaa Essaadouni
Volume/Issue :
Volume 6 - 2021, Issue 4 - April
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3dTqr7K
Abstract :
Systemic lupus erythematosus (SLE) is an
autoimmune disease that can cause kidney damage.
However, lupus-unrelated renal injury has rarely been
described in patients with SLE. We report the
observation of a 28-year-old woman presenting with
vascular purpura, inflammatory joint pain and
abdominal pain. The skin biopsy showed vasculitis while
direct immunofluorescence demonstrated IgA deposits.
Two months later, the patient presented with malar rash
and lower limb edema. She tested positive for antinuclear antibodies (1/1280 with a homogeneous pattern)
and for anti-dsDNA (300 IU). Proteinuria was at
4.18g/24h. Renal biopsy revealed proliferative
glomerulonephritis with IgA deposits. The diagnosis of
SLE and IgA vasculitis with renal involvement was
established. The patient was treated with corticosteroids
and cyclophosphamide.
Keywords :
Systemic Lupus Erythematosus -IgA Vasculitis – Nephropathy
Systemic lupus erythematosus (SLE) is an
autoimmune disease that can cause kidney damage.
However, lupus-unrelated renal injury has rarely been
described in patients with SLE. We report the
observation of a 28-year-old woman presenting with
vascular purpura, inflammatory joint pain and
abdominal pain. The skin biopsy showed vasculitis while
direct immunofluorescence demonstrated IgA deposits.
Two months later, the patient presented with malar rash
and lower limb edema. She tested positive for antinuclear antibodies (1/1280 with a homogeneous pattern)
and for anti-dsDNA (300 IU). Proteinuria was at
4.18g/24h. Renal biopsy revealed proliferative
glomerulonephritis with IgA deposits. The diagnosis of
SLE and IgA vasculitis with renal involvement was
established. The patient was treated with corticosteroids
and cyclophosphamide.
Keywords :
Systemic Lupus Erythematosus -IgA Vasculitis – Nephropathy
