Adverse Drug Reactions (ADRs) are a significant public health concern, and the reporting and monitoring of these events is essential for the identification of potential safety issues with medications. A systemic approach to reporting and monitoring of ADRs includes a comprehensive evaluation of all aspects of the process, including the collection and analysis of ADR data, the reporting mechanisms in place, and the follow-up and response to the reported events. This approach should involve collaboration between healthcare providers, patients, and regulatory agencies, and should leverage technology to enhance the efficiency and accuracy of the process. A robust and systematic approach to ADR reporting and monitoring is critical for ensuring patient safety and improving the quality of healthcare.