Sulphamethoxazole and trimethoprim mixed
ligand and their Mn(II) and Cu(II) metal complexes have
been synthesized and characterized. The characterization
of metal complexes is based on the results of the solubility,
colour, melting points and spectroscopic studies. The UVVisible spectra revealed characteristic wavelength
maxima at 600 nm, 700 nm, 750 nm and 800 nm assigned
to the d-d electronic transition of the metal complexes.
The FTIR results confirmed that the manganese and
copper ions coordinated through the nitrogen atom and
oxygen atom (S=O) of sulphamethoxazole and through
the nitrogen atoms in trimethoprim. The antimicrobial
activities of the metal complexes synthesized indicated
that the metal complexes were more potent against
selected organisms than the free ligands.
Keywords : Sulphamethoxazole, Trimethoprim, Mixed ligands, Metal complexes, Antimicrobial activities, Spectra studies, Characterization.