Authors : Thamer Abd Rehan; Akram sadeq; Ahmad Rahman Salih

Volume/Issue : Volume 9 - 2024, Issue 8 - August

Google Scholar : https://shorturl.at/ViZ4y

Scribd : https://shorturl.at/xkvef

DOI : https://doi.org/10.38124/ijisrt/IJISRT24AUG1311

Abstract : Reaction 0f (thioacetamide/ acetemide) with chloroacetyl chloride to produced N-acetyl-2-chloro (thiocetamide/acetamide), then subsequent reaction with thiosemicarbazide to form N-acetyl-2-(2-carbamothioyl hydrazinyl)thioacetamide/acetamide. Ring closure or Cyclization of these compounds in the presence of sodium hydroxide yield N-(3-mercapto-1,4-dihydro-1,2,4 -triazin-5-yl)ethanethioamide/acetamide. The aim of this contribution is synthesis wide range of triazin derivatives by using different methodologies. These new triazine derivatives will be confirmed by FT- IR, 1HNMR, 13CNMR spectra. Since this triazine ring are very important core in chemical structure of some therapeutic compounds, will be evaluated for biological activities against two types of bacteria and fungi.

Keywords : Heterocycle Compounds, Nitrogen-Containing Heterocycles, Triazine Derivatives, Biological Activities, Antibacterial Activity, Antifungi Activity.

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