Authors :
Shrikant S. Gawandea; Parag S. Kurleb; Jayshree Parikhb; Vijay H. Pethab; Bharti P. Deshmukhb
Volume/Issue :
Volume 8 - 2023, Issue 6 - June
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/y4c9xsdz
DOI :
https://doi.org/10.5281/zenodo.8162453
Abstract :
A series of novel heterocyclic hybrids, N-(4-
(morpholine-4-carbonyl) thiazol-2-yl)-2-(piperazin-1-yl)
acetamide hydrochloride and its sulfonamide derivatives
were synthesized (compound 6a-j) and their structure
was established with the facility of spectroscopic
techniques such as FTIR, 13C NMR, 1H NMR, Mass, etc.
In-vitro antibacterial, antifungal, and antioxidant
activities of the synthesized compounds 6a-j have been
evaluated by using ampicillin, Nystatin, and Ascorbic
acid as the reference standards. Compounds 6b, 6c, 6e,
6g, and 6j have revealed comparable antibacterial
activity by displaying similar MIC values as the
reference standard used. Although antioxidant activities
are seen as ordinary compared to the reference
standard, interestingly compounds 6b, 6e, and 6g have
displayed multi-target inhibitory action against different
microbial, making it a possible choice as a single drug
for the cater of multiple ailments.
A series of novel heterocyclic hybrids, N-(4-
(morpholine-4-carbonyl) thiazol-2-yl)-2-(piperazin-1-yl)
acetamide hydrochloride and its sulfonamide derivatives
were synthesized (compound 6a-j) and their structure
was established with the facility of spectroscopic
techniques such as FTIR, 13C NMR, 1H NMR, Mass, etc.
In-vitro antibacterial, antifungal, and antioxidant
activities of the synthesized compounds 6a-j have been
evaluated by using ampicillin, Nystatin, and Ascorbic
acid as the reference standards. Compounds 6b, 6c, 6e,
6g, and 6j have revealed comparable antibacterial
activity by displaying similar MIC values as the
reference standard used. Although antioxidant activities
are seen as ordinary compared to the reference
standard, interestingly compounds 6b, 6e, and 6g have
displayed multi-target inhibitory action against different
microbial, making it a possible choice as a single drug
for the cater of multiple ailments.
