Authors :
Abel Arikho Abimanyu; Mouli Edward
Volume/Issue :
Volume 9 - 2024, Issue 7 - July
Google Scholar :
https://tinyurl.com/nhz7fh9r
Scribd :
https://tinyurl.com/muz7mvnp
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24JUL707
Abstract :
Osteosarcoma is a rare malignant bone
disease with unclear etiology. It is primarily a disease of
childhood with rapid bone growth in periods of rapid
bone proliferation [such as in puberty]. Before the
1970s, prognosis for this malignancy is very grim with
the only available form of treatment are limb ablation
[amputation]. The advent of modern chemotherapy, in
addition to the development of modern limb salvage
surgery [LSS] techniques, mortality has decreased and
quality of life of surviors have increased. Indonesia is a
developing country with unequal distribution of
adequate health facilities. Studies have shown that
unlike western countries, most osteosarcoma patients in
Indonesia are still treated with limb ablation
procedures. A retrospective descriptive study is done on
Dr. Soetomo General Hospital to discover the surgical
profile of patients undergoing chemotherapy during the
period of 2014-2020. Results have shown that the
majority [26] underwent amputation, 17 underwent no
surgical treatment, and the rest [9] LSS. The results of
this research shows that the clinical reality of
developing nations like Indonesia is still far from the
ideal clinical situation in developed western nations
where these studies originate.
Keywords :
Surgery ; Osteosarcoma ; Developing Nation ;Hospital.
References :
- Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Pediatric and adolescent osteosarcoma. 2009:3-13Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. 9th ed. Baltimore: Williams & Wilkins; 2011.
- Ritter J, Bielack S. Osteosarcoma. Annals of oncology. 2010;21:vii320-vii5.
- Isakoff MS, Bielack SS, Meltzer P, Gorlick R. Osteosarcoma: Current Treatment and a Collaborative Pathway to Success. J Clin Oncol. 2015;33(27):3029-35.
- Jauregui JJ, Nadarajah V, Munn J, Pivec R, Kapadia BH, Lerman DM, et al. Limb Salvage Versus Amputation in Conventional Appendicular Osteosarcoma: a Systematic Review. Indian J Surg Oncol. 2018;9(2):232-40.
- Wenang S, Schaefers J, Afdal A, Gufron A, Geyer S, Dewanto I, et al. Availability and Accessibility of Primary Care for the Remote, Rural, and Poor Population of Indonesia. Front Public Health. 2021;9:721886.
- Mulyanto J, Kringos DS, Kunst AE. Socioeconomic inequalities in healthcare utilisation in Indonesia: a comprehensive survey-based overview. BMJ Open. 2019;9(7):e026164.
- Kamal AF, Widyawarman H, Husodo K, Hutagalung EU, Rajabto W. Clinical outcome and survival of osteosarcoma patients in Cipto Mangunkusumo Hospital: limb salvage surgery versus amputation. Acta Med Indones. 2016;48(3):175-83.
- Ferdiansyah Mahyudin N, Edward M, Basuki MH, Bari YA, Suwandani Y. Osteosarcoma has not become attention to society profile of osteosarcoma patients at dr. Soetomo General Hospital Surabaya “A retrospective study”. Journal Orthopaedi and Traumatology Surabaya. 2018;7(1):20-30.
- Miwa S, Kamei M, Yoshida S, Yamada S, Aiba H, Tsuchiya H, et al. Local dissemination of osteosarcoma observed after massage therapy: a case report. BMC cancer. 2019;19(1):1-6.
- Kalim D. Epidemiologi Osteosarkoma di RSUP Haji Adam Malik Tahun 2012-2017. 2019.
- Lisenda L, Linda ZA, Snyman FPJ, Kyte RD, Lukhele M. Osteosarcoma patient outcomes at a South African tertiary hospital. S Afr Med J. 2017;107(9):754-7.
- Eaton BR, Schwarz R, Vatner R, Yeh B, Claude L, Indelicato DJ, et al. Osteosarcoma. Pediatric blood & cancer. 2021;68:e28352.
- Lindsey BA, Markel JE, Kleinerman ES. Osteosarcoma overview. Rheumatology and therapy. 2017;4(1):25-43.
- Han G, Bi W-Z, Xu M, Jia J-P, Wang Y. Amputation versus limb-salvage surgery in patients with osteosarcoma: a meta-analysis. World journal of surgery. 2016;40(8).
- Wang J, Wu P, Chen P, Yen C, Hung G. Manipulation Therapy Prior to Diagnosis Induced Primary Osteosarcoma Metastasis—. 2014.
- Žganjer M, Bašković M. Osteosarcoma and alternative medicine in children. Pediatria Polska-Polish Journal of Paediatrics. 2022;97(2):165-6.
- Deliana M, Suza DE, Tarigan R. Advanced Stage Cancer Patients Experience in Seeking Treatment in Medan, Indonesia. Open Access Maced J Med Sci. 2019;7(13):2194-203.
Osteosarcoma is a rare malignant bone
disease with unclear etiology. It is primarily a disease of
childhood with rapid bone growth in periods of rapid
bone proliferation [such as in puberty]. Before the
1970s, prognosis for this malignancy is very grim with
the only available form of treatment are limb ablation
[amputation]. The advent of modern chemotherapy, in
addition to the development of modern limb salvage
surgery [LSS] techniques, mortality has decreased and
quality of life of surviors have increased. Indonesia is a
developing country with unequal distribution of
adequate health facilities. Studies have shown that
unlike western countries, most osteosarcoma patients in
Indonesia are still treated with limb ablation
procedures. A retrospective descriptive study is done on
Dr. Soetomo General Hospital to discover the surgical
profile of patients undergoing chemotherapy during the
period of 2014-2020. Results have shown that the
majority [26] underwent amputation, 17 underwent no
surgical treatment, and the rest [9] LSS. The results of
this research shows that the clinical reality of
developing nations like Indonesia is still far from the
ideal clinical situation in developed western nations
where these studies originate.
Keywords :
Surgery ; Osteosarcoma ; Developing Nation ;Hospital.