Surgical Profile of Osteosarcoma Patients in a Tertiary Referral Hospital in Surabaya, Indonesia


Authors : Abel Arikho Abimanyu; Mouli Edward

Volume/Issue : Volume 9 - 2024, Issue 7 - July

Google Scholar : https://tinyurl.com/nhz7fh9r

Scribd : https://tinyurl.com/muz7mvnp

DOI : https://doi.org/10.38124/ijisrt/IJISRT24JUL707

Abstract : Osteosarcoma is a rare malignant bone disease with unclear etiology. It is primarily a disease of childhood with rapid bone growth in periods of rapid bone proliferation [such as in puberty]. Before the 1970s, prognosis for this malignancy is very grim with the only available form of treatment are limb ablation [amputation]. The advent of modern chemotherapy, in addition to the development of modern limb salvage surgery [LSS] techniques, mortality has decreased and quality of life of surviors have increased. Indonesia is a developing country with unequal distribution of adequate health facilities. Studies have shown that unlike western countries, most osteosarcoma patients in Indonesia are still treated with limb ablation procedures. A retrospective descriptive study is done on Dr. Soetomo General Hospital to discover the surgical profile of patients undergoing chemotherapy during the period of 2014-2020. Results have shown that the majority [26] underwent amputation, 17 underwent no surgical treatment, and the rest [9] LSS. The results of this research shows that the clinical reality of developing nations like Indonesia is still far from the ideal clinical situation in developed western nations where these studies originate.

Keywords : Surgery ; Osteosarcoma ; Developing Nation ;Hospital.

References :

  1. Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Pediatric and adolescent osteosarcoma. 2009:3-13Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. 9th ed. Baltimore: Williams & Wilkins; 2011.
  2. Ritter J, Bielack S. Osteosarcoma. Annals of oncology. 2010;21:vii320-vii5.
  3. Isakoff MS, Bielack SS, Meltzer P, Gorlick R. Osteosarcoma: Current Treatment and a Collaborative Pathway to Success. J Clin Oncol. 2015;33(27):3029-35.
  4. Jauregui JJ, Nadarajah V, Munn J, Pivec R, Kapadia BH, Lerman DM, et al. Limb Salvage Versus Amputation in Conventional Appendicular Osteosarcoma: a Systematic Review. Indian J Surg Oncol. 2018;9(2):232-40.
  5. Wenang S, Schaefers J, Afdal A, Gufron A, Geyer S, Dewanto I, et al. Availability and Accessibility of Primary Care for the Remote, Rural, and Poor Population of Indonesia. Front Public Health. 2021;9:721886.
  6. Mulyanto J, Kringos DS, Kunst AE. Socioeconomic inequalities in healthcare utilisation in Indonesia: a comprehensive survey-based overview. BMJ Open. 2019;9(7):e026164.
  7. Kamal AF, Widyawarman H, Husodo K, Hutagalung EU, Rajabto W. Clinical outcome and survival of osteosarcoma patients in Cipto Mangunkusumo Hospital: limb salvage surgery versus amputation. Acta Med Indones. 2016;48(3):175-83.
  8. Ferdiansyah Mahyudin N, Edward M, Basuki MH, Bari YA, Suwandani Y. Osteosarcoma has not become attention to society profile of osteosarcoma patients at dr. Soetomo General Hospital Surabaya “A retrospective study”. Journal Orthopaedi and Traumatology Surabaya. 2018;7(1):20-30.
  9. Miwa S, Kamei M, Yoshida S, Yamada S, Aiba H, Tsuchiya H, et al. Local dissemination of osteosarcoma observed after massage therapy: a case report. BMC cancer. 2019;19(1):1-6.
  10. Kalim D. Epidemiologi Osteosarkoma di RSUP Haji Adam Malik Tahun 2012-2017. 2019.
  11. Lisenda L, Linda ZA, Snyman FPJ, Kyte RD, Lukhele M. Osteosarcoma patient outcomes at a South African tertiary hospital. S Afr Med J. 2017;107(9):754-7.
  12. Eaton BR, Schwarz R, Vatner R, Yeh B, Claude L, Indelicato DJ, et al. Osteosarcoma. Pediatric blood & cancer. 2021;68:e28352.
  13. Lindsey BA, Markel JE, Kleinerman ES. Osteosarcoma overview. Rheumatology and therapy. 2017;4(1):25-43.
  14. Han G, Bi W-Z, Xu M, Jia J-P, Wang Y. Amputation versus limb-salvage surgery in patients with osteosarcoma: a meta-analysis. World journal of surgery. 2016;40(8).
  15. Wang J, Wu P, Chen P, Yen C, Hung G. Manipulation Therapy Prior to Diagnosis Induced Primary Osteosarcoma Metastasis—. 2014.
  16. Žganjer M, Bašković M. Osteosarcoma and alternative medicine in children. Pediatria Polska-Polish Journal of Paediatrics. 2022;97(2):165-6.
  17. Deliana M, Suza DE, Tarigan R. Advanced Stage Cancer Patients Experience in Seeking Treatment in Medan, Indonesia. Open Access Maced J Med Sci. 2019;7(13):2194-203.

Osteosarcoma is a rare malignant bone disease with unclear etiology. It is primarily a disease of childhood with rapid bone growth in periods of rapid bone proliferation [such as in puberty]. Before the 1970s, prognosis for this malignancy is very grim with the only available form of treatment are limb ablation [amputation]. The advent of modern chemotherapy, in addition to the development of modern limb salvage surgery [LSS] techniques, mortality has decreased and quality of life of surviors have increased. Indonesia is a developing country with unequal distribution of adequate health facilities. Studies have shown that unlike western countries, most osteosarcoma patients in Indonesia are still treated with limb ablation procedures. A retrospective descriptive study is done on Dr. Soetomo General Hospital to discover the surgical profile of patients undergoing chemotherapy during the period of 2014-2020. Results have shown that the majority [26] underwent amputation, 17 underwent no surgical treatment, and the rest [9] LSS. The results of this research shows that the clinical reality of developing nations like Indonesia is still far from the ideal clinical situation in developed western nations where these studies originate.

Keywords : Surgery ; Osteosarcoma ; Developing Nation ;Hospital.

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