Studies on Salvation Consequences of Amino Acid in Aqueous Acetaminophen leading to Human Body by Thermodynamic and Physico-Chemical Approaches

Authors : Binoy Chandra Saha, Mahendra Nath Roy

Volume/Issue : Volume 5 - 2020, Issue 2 - February

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Viscosity B-coefficient ,apparent molar volume (φV )Specific conductance and molar refraction (RM) resolute of Acetaminophen solution in different amino acid supplemented with the density (ρ), viscosity (η) and refractive index (nD) and conductance data at various temperature 298.15 K, 303.15 K and 308.15 K respectively at different mass fractions. The limiting apparent molar volumes (φV 0 ) and experimental slopes (SV*) were derived from the Masson equation. (φV = φV 0 + SV * √m),have been interpreted in terms of solute–solvent and solute–solute interactions respectively. (δ2V 0 /δT2 )P values sign ability of the structure making or structure breaking ability of Asparagine and glutamine. The viscosity data were analyzed using the Jones–Dole equation ((η /η0 –1) / √m = A + B √m) and the derived parameter B coefficient has also been interpreted in terms of solute–solvent interactions present in the solutionsThe increase in the transform volume of the solute with acetaminophen concentration was explained by the Friedman and Krishnan Co sphere models. The application of the transition state of the theory has also computed and explained the viscosity activation parameters for the studied solutions.Molar refraction (RM 2 2 1 2 D D n m n                     ) has been calculated using the Lorentz - Lorenz equation. Molecular interaction of two amino acids in acetaminophen solution in aqueous medium was investigated by conducting moles at three different temperatures.

Keywords : Acetaminophen ,Asparagines , Glutamine ,Solute-Solvent, Interactions, Apparent Molar Volume, Viscosity, Conductance.


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