The Mucoadhesive drug delivery system was a new approach in pharmaceutical field and drug retention for a prolonged time has been achieved. Rosuvastatin calcium is a HMG-CoA Reductase inhibitors (statins) used in the treatment of percholesterolemia or hyperlipidemia. Mucoadhesive micro beads of Rosuvastatin calcium were successfully prepared by Ionotropic gelation technique. Central composite design was applied for the preparation and optimization of mucoadhesive microbeads using Statease-Design of Experiment Version–12 software. The results of preformulation studies showed that there was no interaction between the drug and polymer. The polymers used in the microbeads are Sodium Alginate, HPMC. Mucoadhesive microbeads were obtained by Ionotropic gelation method for all the formulations from F1 to F9. Formulations F1 to F9 were prepared with different concentration of polymer and with constant drug ratio of Rosuvastatin Calcium. All formulations were evaluated for the Percentage yield, Particle size, Drug content, Entrapment efficiency, Scanning electron Microscopy, Swelling study, mucoadhesion testing, invitro drug release profile. From the overall studies it can be concluded that the formulation F9 considered as the best formulation among nine formulations by comparing all the evaluated parameters.

Keywords : Microbeads, Central Composite Design, Rosuvastatin calcium, in-vitro drug release studies.