Studies on Formulation and in-Vitro Evaluation of Mouth Dissolving Tablets Containing Telmisartan by using Box-Benkhen Design


Authors : T. AYYAPPAN; A.V.ARCHANA; B.MANOJ; Dr .T.AYYAPPAN

Volume/Issue : Volume 8 - 2023, Issue 2 - February

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3YUzSZ7

DOI : https://doi.org/10.5281/zenodo.7648002

New era is an era of novel drug delivery systems. Pediatric, Geriatric and bed ridden patients have difficulties in swallowing tablets. The purpose of the present study was to develop and characterize mouth dissolving tablets of Telmisartan by using direct compression technique. Formulations were designed by factorial design technique. Sodium Saccharine, Cross povidone and Banana powder were used as a superdisintegrants while microcrystalline cellulose was used as diluents. The powder blends were prepared and evaluated for the properties such as angle of repose, loose bulk density, tapped bulk density, carr’s compressibility index and hausner’s ratio. Tablets were evaluated for hardness, friability, drug content, disintegration time, water absorption ratio, in vitro drug release in methanol. Formulation containing Crospovidone and Sodium Saccharine in higher concentration showed a rapid disintegration, wetting and in vitro drug release as compared to other formulations. Dispersion time indicate complete dispersion of formulation . Quick dispersion of formulations favours fast disintegration of formulations. The perturbation plot shows the super disintegration has the major contribution on prepared dosage form .

Keywords : Direct compression; Factorial design; Telmisartan; Mouth dissolving tablets; Super disintegrants

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