Authors :
T. AYYAPPAN; A.V.ARCHANA; B.MANOJ; Dr .T.AYYAPPAN
Volume/Issue :
Volume 8 - 2023, Issue 2 - February
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3YUzSZ7
DOI :
https://doi.org/10.5281/zenodo.7648002
Abstract :
New era is an era of novel drug delivery
systems. Pediatric, Geriatric and bed ridden patients
have difficulties in swallowing tablets. The purpose of
the present study was to develop and characterize mouth
dissolving tablets of Telmisartan by using direct
compression technique. Formulations were designed by
factorial design technique. Sodium Saccharine, Cross
povidone and Banana powder were used as a
superdisintegrants while microcrystalline cellulose was
used as diluents. The powder blends were prepared and
evaluated for the properties such as angle of repose,
loose bulk density, tapped bulk density, carr’s
compressibility index and hausner’s ratio. Tablets were
evaluated for hardness, friability, drug content,
disintegration time, water absorption ratio, in vitro drug
release in methanol. Formulation containing
Crospovidone and Sodium Saccharine in higher
concentration showed a rapid disintegration, wetting and
in vitro drug release as compared to other formulations.
Dispersion time indicate complete dispersion of
formulation . Quick dispersion of formulations favours
fast disintegration of formulations. The perturbation
plot shows the super disintegration has the major
contribution on prepared dosage form .
Keywords :
Direct compression; Factorial design; Telmisartan; Mouth dissolving tablets; Super disintegrants
New era is an era of novel drug delivery
systems. Pediatric, Geriatric and bed ridden patients
have difficulties in swallowing tablets. The purpose of
the present study was to develop and characterize mouth
dissolving tablets of Telmisartan by using direct
compression technique. Formulations were designed by
factorial design technique. Sodium Saccharine, Cross
povidone and Banana powder were used as a
superdisintegrants while microcrystalline cellulose was
used as diluents. The powder blends were prepared and
evaluated for the properties such as angle of repose,
loose bulk density, tapped bulk density, carr’s
compressibility index and hausner’s ratio. Tablets were
evaluated for hardness, friability, drug content,
disintegration time, water absorption ratio, in vitro drug
release in methanol. Formulation containing
Crospovidone and Sodium Saccharine in higher
concentration showed a rapid disintegration, wetting and
in vitro drug release as compared to other formulations.
Dispersion time indicate complete dispersion of
formulation . Quick dispersion of formulations favours
fast disintegration of formulations. The perturbation
plot shows the super disintegration has the major
contribution on prepared dosage form .
Keywords :
Direct compression; Factorial design; Telmisartan; Mouth dissolving tablets; Super disintegrants
