Studies on effects of Gmelina arborea bark aqueous extract in glucose level and pancreatic histology of experimentally induced albino rats were undertaken. Twenty albino rats were used for this study. The animals were grouped into five, containing four each. Normal control(group I ) administered 0.4ml/Kg.bw. distilled water, group II(0.4ml/Kg.bw. alloxan monohydrate) group III(0.4ml./Kg.bw of alloxan + 0.5ml/Kg.bw. glibenclamide, group IV ( 0.4ml/Kg.bw. alloxan + 200mg/Kg.bw. Gmelina arborea stem bark aqueous extract) and group V received 0.4ml/Kg.bw. alloxan + 400mg/Kg.bw. extract. The treatments were orally administered daily to the albino rats for twenty-one days. The fasting blood glucose levels were measured on day 0, 1,7,14 and 21. On 21st day after the blood glucose measurement, all the animals were sacrificed and their pancreas were removed and processed for histological examination.

Keywords : Antidiabetic , Hyperglycemia, Glucose level, Pancreas, Gmelina arborea, Alloxan.