The Role of Alleviate Oxidative Stress of Oxytocin in The Neurodegenerative Disorders


Authors : Hasan A. M. M. Almansoub; Rowdh Almansoob

Volume/Issue : 2nd ICTSA-2022

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://bit.ly/3ZenW4q

DOI : https://doi.org/10.5281/zenodo.7765559

Neurodegenerative diseases are characterized by progressive damage in neural cells and neuronal loss; bearing in mind the relevance of oxidative stress in neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, and the antioxidant properties of oxytocin, which we previously demonstrated, we studied the effects of oxytocin administration 5µM oxytocin for 24h, on enzymatic activities of superoxide dismutase (SOD) and malonic dialdehyde (MDA) level in the Neuro2a cells (N2a cell lines ) which treated by 250 µM hydrogen peroxide( H2O2 ) for 24h. In these cells, oxytocin treatment provided a significantly lower SOD enzymatic activity and significantly higher MDA concentration. It is concluded that, due to its antioxidant effect, oxytocin can be considered a candidate for developing a new therapeutic modality in neurodegenerative diseases.

Keywords : Neurodegenerative Diseases, Oxidative Stress, Oxytocin, Superoxide Dismutase, Malonic Dialdehyde, Neuro2a cells.

CALL FOR PAPERS


Paper Submission Last Date
29 - February - 2024

Paper Review Notification
In 1-2 Days

Paper Publishing
In 2-3 Days

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe