Neurodegenerative diseases are characterized by progressive damage in neural cells and neuronal loss; bearing in mind the relevance of oxidative stress in neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, and the antioxidant properties of oxytocin, which we previously demonstrated, we studied the effects of oxytocin administration 5µM oxytocin for 24h, on enzymatic activities of superoxide dismutase (SOD) and malonic dialdehyde (MDA) level in the Neuro2a cells (N2a cell lines ) which treated by 250 µM hydrogen peroxide( H2O2 ) for 24h. In these cells, oxytocin treatment provided a significantly lower SOD enzymatic activity and significantly higher MDA concentration. It is concluded that, due to its antioxidant effect, oxytocin can be considered a candidate for developing a new therapeutic modality in neurodegenerative diseases.

Keywords : Neurodegenerative Diseases, Oxidative Stress, Oxytocin, Superoxide Dismutase, Malonic Dialdehyde, Neuro2a cells.