Treatment Adherence is as important as the air a mentally-ill person breathes, and it’s a long term issue while religious practices is a factor that may influence either positively or negatively. To determine the influences of religious practices on treatment adherence among the mentally-ill attending the out-patient clinic of a Neuropsychiatric Hospital, Abeokuta. Both quantitative (cross sectional survey) and qualitative (focus group discussion) designs was utilized for the study. The target populations for the study were the patients attending the out-patient clinic of Neuropsychiatric hospital, Abeokuta. The sample included 167 participants that answered the questionnaires and four focus group discussions consisting of 40 participants. Simple random sampling was used to select the participants.  Results: The overall treatment adherent level reveals that majority of the respondents where adherent (63.7%), 6.6% were non adherent while 28.7% were neutral. 86.8% agreed that their religious practices do not affect their treatment adherence but 13.2 said religious practices influence their treatment adherence. Despite the fact that 59.3% of the participants were unemployed, the rate of treatment adherence was still high among the respondents and 55.7% said side effect of the drug do not affect their drug compliance. The study concluded that the respondents were adherent and that religious practice do not influence their treatment adherence.

Keywords : Mentally-ill, Out-patient, Religious Practice, Treatment Adherence