Authors : Intissar Belrhali; Khaoula OUCHEN; Soufiane Bel Rhali; Oumaima Lamsyah; Boutaina CHERKAOUI; Stephane Ruck; Sarah NACIRI; Hassan Errihani

Volume/Issue : Volume 9 - 2024, Issue 8 - August

Google Scholar : https://tinyurl.com/ms7usa47

Scribd : https://tinyurl.com/9wk859ah

DOI : https://doi.org/10.38124/ijisrt/IJISRT24AUG163

Abstract : Hypercalcemia during cancer progression may reflect the expression of hypersecretion of PTH-related peptide (PTH-rp). This observation illustrates the possibility of malignant humoral hypercalcemia (MHH) in penile cancer in an 82-year-old patient treated at the Émile Durkheim Hospital in Épinal, France.

Keywords : Squamous Cell Carcinoma, Penile Cancer, Hypercalcemia, Humoral Hypercalcemia of Malignancy, Surge ry , Urologic Oncology.

References :

1. Daubisse-Marliac L., Colonna M., Trétarre B., Defossez G., Molinié F., Jéhannin-Ligier K., et al. Long-term trends in incidence and survival of penile cancer in France Cancer Epidemiol 2017 ;  50 : 125-13110.1016/j.canep.2017.08.014.
2. N. Mottet. Epidemiologie du cancer du penis [Epidemiology of penile cancer] Prog. Urol., 13 (5 Suppl 2) (2003 Nov), p. 1237.
3. Lont A.P., Kroon B.K., Horenblas S., Gallee M.P.W., Berkhof J., Meijer C.J.L.M., et al. Presence of high-risk human papillomavirus DNA in penile carcinoma predicts favorable outcome in survival Int J Cancer 2006 ;  119 : 1078-108110.1002/ijc.21961.
4. FRENCH AFU CANCER COMMITTEE GUIDELINES – UPDATE 2022-2024: PENILE CANCER https://www.urofrance.org/recommandation/french-afu-cancer-committee-guidelines-update-2022-2024-penile-cancer/
5. Hakenberg O., Compérat E., Minhas S., Necchi A., Protzel C., Watkin N. EAU Guidelines on Penile Cancer  :  (2022). penile-cancer.
6. Dorfinger K, Maier U, Base W. Parathyroid hormone related pro- tein and carcinoma of the penis:paraneoplastic hypercalcemia. J Urol. 1999;161(5):1570.
7. Everett Anderson EE, Glenn JF. Penile malignancy and hypercal- cemia. JAMA. 1965;192(4):328-329.
8. Malakoff AF, Schmidt JD. Metastatic carcinoma of penis compli- cated by hypercalcemia. Urology.1975;5(4):510-513.
9. Trejo-Rosales R, Nevarez-Barragan MJ, Rosas-Jurado MG, Perez- Diaz I, Bezaury AP. Rare association between penile squamous cell carcinoma and parathyroid related peptide (PTH-rP) secretion. Arq Bras Endocrinol Metabol.2014;58(6):646-649.
10. Sardiñas Z, Suazo S, Kumar S, Lee A, Rosenthal DS. Ectopic parathyroid hormone secretion by a penile squamouscell carci- noma. AACE Clin Case Rep. 2018;4(1):9-12.
11. Gandhi SJ, Rabadiya B. Extensive visceral calcification demon- strated on 99mTc-MDP bone scan in patient with carcinoma penis and hypercalcemia of malignancy. Indian J Nucl Med. 2017; 32(2):150-152.
12. Kanta R, Ansari MJU, Ali M, et al. Humoral hypercalcemia of malignancy caused by squamous cell carcinoma ofthe penis. J Endocr Soc. 2020;4.
13. Ho CCK, Nazri J, Zu MZ, et al. Metastatic Penile Cancer Present- ing as Hypercalcemia and pathological Fracture of the humerus: a rare event. Med JMalays. 2006;61:503-505.
14. Bower M, Cox S. Endocrine and metabolic complications of advanced cancer. In: Doyle D, Hanks G, Cherny NI, Calman K, editors. Oxford textbook of palliative medicine. 3e éd. New York, NY: Oxford University Press; 2004. pp. 688–90. 
15. Solimando DA. Overview of hypercalcemia of malignancy. Am J Health Syst Pharm. 2001;58(Suppl 3):S4–7. 
16. Stewart AF. Clinical practice. Hypercalcemia associated with cancer. N Engl J Med. 2005;352(4):373–9. 
17. Twycross R, Wilcock A.  Symptom management in advanced cancer. 3e éd. Oxon, Royaume-Uni: Radcliffe Medical Press; 2001. pp. 215–21. 
18. Lumachi F, Brunello A, Roma A, Basso U. Cancer-induced hypercalcemia. Anticancer Res. 2009;29(5):1551–5.
19. Major P, Lortholary A, Hon J, Abdi E, Mills G, Menssen HD, et al. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Oncol. 2001;19(2):558–67.