To describe the seroprevalence of rotavirus
infection among children who were admitted with acute
diarrhea to Al-Sabeen Hospital for Women and
Children after the introduction of Rotavirus vaccine as
part of the National Yemeni Immunization Program in
Sana’a city, Yemen and to determine some risk factors
for getting rotavirus infection.
It was a cross-sectional prospective study that
conducted from January 2016 to November 2016 on
children aged ≤ 5 years with acute watery diarrhea (≤14
days duration) and admitted for the treatment of
gastroenteritis as a primary illness. The demographic
and clinical data of the patients were collected
according to a structured questionnaire. Four to eight
grams of stool samples were collected from each
participant and Rotavirus was detected by ELISA
according to the manufacture instruction enclosed
(ProSpecTTM RV Microplate Assay, Oxoid Ltd, UK).
A total of 400 children were enrolled. Rotavirus
infection was detected in 118 (29.5%) children. Among
those children who infected with RV there were 60
(50.8%) vaccinated and 58 (49.2%) were unvaccinated.
Rotavirus infection is widespread among Yemeni
children with diarrhea despite the introduction of the
Rotavirus vaccine in the Yemeni National Program for
Immunization in Sana’a city. The efficiency of the
Rotavirus vaccine is questionable and further studies
are needed to reveal the reasons of this low efficacy rate
of the vaccine.
Keywords : Rotavirus, Vaccine, Yemen.