Authors : Daniwing Putri Sahudi

Volume/Issue : Volume 10 - 2025, Issue 2 - February

Google Scholar : https://tinyurl.com/3nnkf5fz

Scribd : https://tinyurl.com/mtkmcjy3

DOI : https://doi.org/10.5281/zenodo.14979482

Abstract : The ageing process of the skin is complex and impacted by both internal and external causes. As the skin's antioxidant system deteriorates with age, a well-known hypothesis of ageing holds that oxidative damage causes cellular senescence or apoptosis. The complex ecosystem that is the human microbiota is made up of bacteria, fungi, and viruses, among other microorganisms. Both innate and adaptive immune responses depend on the gut and skin microbiota's ability to modulate the immune system, manage inflammation, and protect against invasive infections. Throughout life, the human microbiome may change and be impacted by a variety of disruptions. "Microbial dysbiosis," a change in the gut microbiota, is connected to the effects of a number of illnesses, including ageing. An innovative synthesis of the "genome- microbiome-exposome," the skin interactome has a major impact on skin health and ageing. In order to protect, prevent, and postpone skin ageing while preserving good skin conditions, future initiatives should concentrate on reducing the negative effects of factors that affect the skin interactome.

Keywords : Skin microbiome, Aging, Immunological Response.

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