Authors : Mudassir Alam; Kashif Abbas; Mohd Tanjeem Raza; Sana Asif; Aharas Siddiqui; Zulnurain Khan

Volume/Issue : Volume 8 - 2023, Issue 12 - December

Google Scholar : https://tinyurl.com/ycyd33ku

Scribd : https://tinyurl.com/58v6k246

DOI : https://doi.org/10.5281/zenodo.10300800

Abstract : Diabetes mellitus, a pervasive global health concern characterized by elevated blood glucose levels, necessitates innovative therapeutic approaches for enhanced efficacy and improved patient compliance. Nanotechnology, operating at the nanoscale (1-100 nanometers), presents a transformative paradigm in medicine—nanomedicine—that holds promise for revolutionizing drug delivery systems. This review explores nanotechnology's potential in reshaping diabetes management, with a focus on optimizing drug delivery for diabetes control. Nanoparticles, including liposomes, polymeric nanoparticles, and dendrimers, offer controlled release kinetics, improved bioavailability, and targeted delivery. Exploiting enhanced permeability and retention, these formulations selectively accumulate therapeutic agents in diabetic tissues. Smart nanoparticles, equipped with sensors and feedback mechanisms, respond to fluctuating glucose levels, providing real-time personalized therapy. Beyond drug delivery, nanosensors detecting diabetes-associated biomarkers offer insights into disease progression. This integrated approach aligns with personalized medicine, tailoring treatments to individual profiles. This review critically analyzes existing knowledge, spanning materials science, pharmacology, and bioengineering, contributing to discussions on nanotechnology's transformative role in diabetes care. The goal is to usher in innovative therapeutic strategies, advancing diabetes management into a new era of precision medicine for improved patient outcomes and reduced treatment-related burdens.

Keywords : Nanotechnology, Diabetes, Drug-Delivery, Liposomes, Nano-Particles.