Malaria is a tropical disease that infects almost all people in Papua, as an endemic area with the highest Annual Parasite Incidence (API=95%) in all of Indonesia. The government's program is intense in elimination malaria with a target of reducing the API by 2030 to the level of 1/1,000, while the Papua Provincial Health Office reports that the 2017 API is 95 cases per 1,000 population. The Genyem Primary Health Center is one of the areas with the highest malaria cases in Jayapura Regency. This study is to prove the level of knowledge of malaria sufferers about the use of LLINs mosquito nets is a risk factor for the incidence of malaria in the Genyem Primary Health Center area. This study used a mixed method design on 81 subjects with malaria who were written on the medical records of the Genyem Health Center (cases) by comparing 81 subjects who did not suffer from malaria (controls) who lived around malaria sufferers (cases). Data were analyzed using chi square test and estimated value of Odd Ratio (OR). The results of this study prove that the level of knowledge of malaria sufferers who lack knowledge about the use of LLINs is proven to be a risk factor for the incidence of malaria ( = 0.001) and subjects who have a low level of knowledge about the use of LLINs have a risk of 4.23 times being infected with malaria compared to subjects with a good level of knowledge (OR: 4.23;95CI: 1.851-9.669). Lack of knowledge of malaria sufferers is a risk factor for the incidence of malaria. It’s recommended that counseling on the use of LLINs be held to increase public knowledge about how to wash, how to dry, and how to care for insecticide-treated mosquito nets (LLINs) and that LLINs mosquito net suppliers should replace LLINs materials that are comfortable for the community to use in realizing a malaria-free Papuan society by 2030.

Keywords : Risk Factor, Incidence Malaria, Level of Knowledge, LLINS.