Review: Novel Drug Delivery for the Treatment of Osteoarthritis (OA)


Authors : Kajal; Dev Raj Sharma; Vinay Pandit; M.S. Ashawat

Volume/Issue : Volume 7 - 2022, Issue 5 - May

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3944yTF

DOI : https://doi.org/10.5281/zenodo.6605007

As people live longer, the prevalence of osteoarthritis has increased, making it the most frequent kind of arthritis. During osteoarthritis, tissue of cartilage on articular joints corrodes, causing pain and sometimes debilitating loss of function in patients. The most significant risk factor for osteoarthritis is getting older. Osteoarthritis, is the most common chronic joint illness, and becomes common nowadays as people become older. It disturbs the majority of people over 65 and is a main musculoskeletal reason of reduced mobility in the elderly. Because the particular molecular mechanisms behind the degradation of cartilage matrix and the development of OA are unknown, there are presently no viable therapies to slow the advancement of OA or prevent irreversible cartilage degradation other than total joint replacement surgery. The major molecular pathways involved in OA pathogenesis will be discussed in this study, as well as new insights into prospective molecular targets. Various Novel carrier are used to enhancement of drug delivery to the site of action.

Keywords : Osteoarthritis(OA),Aging, Cartilage,Distruction,Nanocarrier

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