Authors :
Dr. Rohit Sane; Dr. Gurudatta Amin; Dr. Pravin Ghadigaonkar; Dr. Bipin Gond; Dr. Manjusha Kulthe
Volume/Issue :
Volume 11 - 2026, Issue 5 - May
Google Scholar :
https://tinyurl.com/yc67zhc8
Scribd :
https://tinyurl.com/45fyzy6y
DOI :
https://doi.org/10.38124/ijisrt/26May1798
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Background:
Resting heart rate (RHR) elevation is an independent predictor of cardiovascular mortality in type 2 diabetes mellitus
(T2DM), reflecting underlying sympathetic overdrive and autonomic dysregulation. Despite its clinical significance, RHR is
rarely reported as an outcome in integrative diabetes intervention studies. The present study examines RHR as a primary
cardiovascular endpoint alongside glycemic and anthropometric outcomes in T2DM patients treated with a structured
Ayurvedic multimodal protocol.
Objectives:
To evaluate the effect of the CDC Ayurvedic multimodal protocol — comprising BMI-stratified Panchakarma (CDC-SP
and CDC-KP), Prameha diet, and individualized herbal therapy — on resting heart rate, glycemic parameters, and
cardiometabolic risk markers in T2DM patients; and to examine the pattern of response across multiple treatment cycles.
Keywords :
Resting Heart Rate, Type 2 Diabetes, Autonomic Dysregulation, Panchakarma, Basti, Ayurveda, Cardiovascular Risk, HbA1c, Nashik, Sympathetic Overdrive, CDC Protocol.
References :
- Custodis F, et al. Heart rate and heart failure. Circulation Journal. 2010;74(7):1282–1292.
- Morcet JF, et al. Associations between heart rate and other risk factors among a large French population. Journal of Hypertension. 1999;17(12):1671–1676.
- Vinik AI, et al. Diabetic autonomic neuropathy. Diabetes Care. 2003;26(5):1553–1579.
- Agarwal V, et al. Panchakarma therapy in the management of type 2 diabetes — A systematic review. Journal of Ayurveda and Integrative Medicine. 2020;11(3):323–330.
- Singhal HK, et al. Ayurvedic approach for research on diabetes mellitus. Recent Patents on Endocrine, Metabolic and Immune Drug Discovery. 2010;4(3):218–228.
- Charaka Samhita. Chikitsa Sthana, Chapter 6: Prameha Chikitsa. Varanasi: Chaukhamba Surbharati Prakashan.
- Field T. Massage therapy research review. Complementary Therapies in Clinical Practice. 2016;24:19–31.
- Charaka Samhita. Nidana Sthana, Chapter 4: Prameha Nidanam. Varanasi: Chaukhamba Surbharati Prakashan.
- Rapaport MH, et al. Modification of Swedish massage context affects heart rate variability. Journal of Alternative and Complementary Medicine. 2012;18(4):360–367.
- Sharma R, et al. Pharmacological properties of Dashmula — a polyherbal Ayurvedic formulation. International Journal of Pharmaceutical Sciences and Research. 2014;5(7):2625–2633.
- Lean MEJ, et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT). Lancet. 2018;391(10120):541–551.
- American Diabetes Association. Standards of Medical Care in Diabetes — 2023. Diabetes Care. 2023;46(Supplement 1).
- Liang X, et al. Effects of berberine on cardiac failure in rats. Journal of Chinese Integrative Medicine. 2010;8(12):1142–1148.
- Hubert HB, et al. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983;67(5):968–977.
- Bonaz B, et al. The vagus nerve at the interface of the microbiota-gut-brain axis. Frontiers in Neuroscience. 2018;12:49.
Background:
Resting heart rate (RHR) elevation is an independent predictor of cardiovascular mortality in type 2 diabetes mellitus
(T2DM), reflecting underlying sympathetic overdrive and autonomic dysregulation. Despite its clinical significance, RHR is
rarely reported as an outcome in integrative diabetes intervention studies. The present study examines RHR as a primary
cardiovascular endpoint alongside glycemic and anthropometric outcomes in T2DM patients treated with a structured
Ayurvedic multimodal protocol.
Objectives:
To evaluate the effect of the CDC Ayurvedic multimodal protocol — comprising BMI-stratified Panchakarma (CDC-SP
and CDC-KP), Prameha diet, and individualized herbal therapy — on resting heart rate, glycemic parameters, and
cardiometabolic risk markers in T2DM patients; and to examine the pattern of response across multiple treatment cycles.
Keywords :
Resting Heart Rate, Type 2 Diabetes, Autonomic Dysregulation, Panchakarma, Basti, Ayurveda, Cardiovascular Risk, HbA1c, Nashik, Sympathetic Overdrive, CDC Protocol.