Authors : Thakir U. Mohsen

Volume/Issue : Volume 11 - 2026, Issue 5 - May

---

Google Scholar : https://tinyurl.com/3up87n4e

Scribd : https://tinyurl.com/sd7xxwtu

DOI : https://doi.org/10.38124/ijisrt/26May1696

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

---

Abstract : The present experiment was conducted in the middle region of Iraq in 2023 on 120 Awassi unimproved breed ewes to determine the effect of LMO4 gene polymorphism on lactation period and milk yield. The LMO4 gene position 20782 consisted of two co-dominant alleles with three genotypes. The results showed a notable difference (P≤0.01) at the distribution of the samples according to the alleles that were brought about by single nucleotide polymorphism at both places.

Keywords : LMO4 Gene, Awassi Sheep, Milk Production.

References :

1. Amin, A.Y. and K. J. Peters. 2006. Awassi Sheep Production and the Development of breeding Program Options in Syria. Tropentag, October 11-13, 2006, Bonn “Prosperity and Poverty in a Globalised World. Challenges for Agricultural Research”.
2. Mohammadabadi, M. R. ; F. Bordbar and J. Jensen. 2021. Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals. DOI: 10.3390/ani11030835.
3. Chang, D.F.; Belaguli, N.S.; Iyer, D.; Roberts, W.B.; Wu, S.; Dong, X.; Marx, J.G.; Moore, M.S.; Beckerle, M.C.; Majesky, M.W.2003. Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev. Cell 2003, 4, 107–118. [CrossRef].
4. Liu, R.; Sun, Y.; Zhao, G.; Wang, H.; Zheng, M.; Li, P.; Liu, L.; Wen, J. 2015. Identification of loci and genes for growth related traits from a genome-wide association study in a slow- _ fast-growing broiler chicken cross. Genes Genomics 2015, 37, 829–836. [CrossRef].    
5. Zhao, Y.; Li, J.; Liu, H.; Xi, Y.; Xue, M.; Liu,W.; Zhuang, Z. and M. Lei. 2015. Dynamic transcriptome profiles of skeletal muscle tissue across 11 developmental stages for both Tongcheng and Yorkshire pigs. BMC Genomics 2015, 16, 377. [CrossRef].
6. Kostek, M.C.; Chen, Y.; Cuthbertson, D.J.; Shi, R.; Fedele, M.J.; Esser, K.A.; Rennie, M.J.2007. Gene expression responses over 24 hto lengthening and shortening contractions in human muscle: Major changes in CSRP3, MUSTN1, SIX1, and FBXO32. Physiol.Genomics 2007, 31, 42–52. [CrossRef].
7. Sambrook, J. and D. Russell.2001. Molecular Cloning: A Laboratory  Manual. 3^rd  ed. Cold Spring Harbor. New York. USA.
8. SAS. 2012. Statistical Analysis System, User's Guide. Statistical. Version 9. 1th ed. SAS. Inst. Inc. Cary. N.C. USA.          
9. Duncan,  D.B. 1955.  Multiple Range and Multiple F Tests. Biometrics, 11 :1- 41.
10. Galal, S.; Gursoy, O.; Shaat, I. Awassi sheep as a genetic resource and efforts for their genetic improvement-A review. Small Rumin. Res. 2008, 79, 99–108. [Google Scholar] [CrossRef].
11. Bittante, G.; Cipolat-Gotet, C.; Pazzola, M.; Dettori, M.L.; Vacca, G.M.; Cecchinato, A. Genetic analysis of coagulation properties, curd firming modeling, milk yield, composition, and acidity in Sarda dairy sheep. J. Dairy Sci. 2017, 100, 385–394. [Google Scholar] [CrossRef].
12. Sanchez, M.P.; Ramayo-Caldas, Y.; Wolf, V.; Laithier, C.; El Jabri, M.; Michenet, A.; Boussaha, M.; Taussat, S.; Fritz, S.; Delacroix-Buchet, A.; et al. Sequence-based GWAS, network and pathway analyses reveal genes co-associated with milk cheese-making properties and milk composition in Montbeliarde cows. Genet. Sel. Evol. 2019, 51, 34. [Google Scholar] [CrossRef] [Green Version]
13. Ramakrishnan, M.; Eaton, T.K.; Sermet, O.M.; Savaiano, D.A. Milk Containing A2 beta-Casein ONLY, as a Single Meal, Causes Fewer Symptoms of Lactose Intolerance than Milk Containing A1 and A2 beta-Caseins in Subjects with Lactose Maldigestion and Intolerance: A Randomized, Double-Blind, Crossover Trial. Nutrients 2020, 12, 3855. [Google Scholar] [CrossRef].
14. Manetopoulos C, Hansson A, Karlsson J, Jonsson JI, Axelson H (2003) The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Biochem Biophys Res Commun 307 (4):891–899. doi:10.1016/s0006–291x(03)01298–1 [PubMed] [Google Scholar].
15. Novotny-Diermayr V, Lin B, Gu L, Cao X (2005) Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction. J Biol Chem 280 (13):12747–12757. doi:10.1074/jbc.M500175200 [PubMed] [Google Scholar]
16. Schock SC, Xu J, Duquette PM, Qin Z, Lewandowski AJ, Rai PS, Thompson CS, Seifert EL, Harper ME, Chen HH (2008) Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4. J Neurosci 28 (47):12433–12444. doi:10.1523/JNEUROSCI.2897–08.2008 [PMC free article] [PubMed] [Google Scholar]
17. Rosati R, Shahab M, Neumann WL, Jamesdaniel S (2019) Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells. Exp Cell Res 381 (1):105–111. doi:10.1016/j.yexcr.2019.05.008 [PMC free article] [PubMed] [Google Scholar].