Practical knowledge of basic nursing laboratory I is considered the basic skills for grade I students. Laboratory practical skills are important because they teach about basic nursing techniques to meet the basic needs of everyday humans that are commonly encountered. This study aims to determine the relationship between knowledge and skills of students of Level II students in Doing Basic Nursing Laboratory Practices I. The type of research used is descriptive analytic with cross sectional approach techniques. The data analysis used was Univariate and Bivariate analysis. Bivariate analysis performed the Spearman Rank Correlation test. The results of the study there is a relationship between the level of knowledge and the skills of Level II students in performing basic nursing laboratory practice I at the Academy of Nursing Central Tapanuli Regency with a ρ value of 0.04 and a value of α = 0.05 is obtained. It is hoped that there will be an increase in the knowledge and skills of students about Basic Nursing Laboratory Practice I by meeting the appropriate demonstration laboratory practice schedule related to Basic Nursing Laboratory Practice I on an ongoing basis

Keywords : Knowledge, Skills, Basic Nursing Laboratory Practices Action