Authors :
Triska Antony Manday; Selvi Nafianti; Yazid Dimyati; Sri Sofyani; Rita Evalina; Juliandi Harahap
Volume/Issue :
Volume 7 - 2022, Issue 8 - August
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3w8DR8u
DOI :
https://doi.org/10.5281/zenodo.6997210
Abstract :
Patients with acute lymphoblastic leukemia
(ALL) undergoes chemotherapy treatment. The side
effects of chemotherapy correlated to gastrointestinal
system were reported in 40% in-patients going through
standard risk chemotherapy and all (100%) in-patients
receiving high-risk chemotherapy. Some of the side
effects of chemotherapy on the gastrointestinal system in
ALL patients include decreased appetite, cachexia,
fatigue, perianal dermatosis, even hemorrhoid due to
constipation, as well as prolonged mucositis. These
conditions physically and psychologically interfere with
children activity and negatively impact the quality of life.
This research studied the relationship between the side
effects of chemotherapy specifically on the
gastrointestinal system and the QOL of pediatric ALL
patients so that appropriate follow-up procedures to
improve QOL during chemotherapy can be planned. This
was a cross-sectional study carried out at the
Hematology-Oncology division Haji Adam Malik
hospital. The research subjects were pediatric ALL
patients aged between 2 and 18 years old, meeting the
inclusion and exclusion criteria. Sampling technique was
consecutive sampling. The relationships between the
dependent variable (QOL) and independent variables
(chemotherapy protocol and duration and side effects)
were assessed by Chi-square, Mann-Whitney, and
Fischer’s exact tests. Multivariate analysis was used to
determine the most dominant independent variable
affecting the QOL of pediatric ALL patients undergoing
chemotherapy. No significant relationship between
chemotherapy protocol and QOL (p=0.435). No
significant relationship between the duration of
chemotherapy and QOL (p>0.05). There were significant
relationships between chemotherapy-induced
gastrointestinal disorder symptoms and QOL, such as
oral mucositis (p=0.001), nausea (p=0.037), vomiting
(p=0.001), and diarrhea (p=0.006). From the multivariate
analysis, three independent variables that could predict
the QOL of pediatric ALL patients were oral mucositis
(p=0.002), nausea (p=0.040), and vomiting (p=0.019).
Chemotherapy procedures for ALL treatment on
pediatric patients showed a poor QOL.
Keywords :
chemotherapy, quality of life, gastrointestinal system, acute lymphoblastic leukemia, pediatric.
Patients with acute lymphoblastic leukemia
(ALL) undergoes chemotherapy treatment. The side
effects of chemotherapy correlated to gastrointestinal
system were reported in 40% in-patients going through
standard risk chemotherapy and all (100%) in-patients
receiving high-risk chemotherapy. Some of the side
effects of chemotherapy on the gastrointestinal system in
ALL patients include decreased appetite, cachexia,
fatigue, perianal dermatosis, even hemorrhoid due to
constipation, as well as prolonged mucositis. These
conditions physically and psychologically interfere with
children activity and negatively impact the quality of life.
This research studied the relationship between the side
effects of chemotherapy specifically on the
gastrointestinal system and the QOL of pediatric ALL
patients so that appropriate follow-up procedures to
improve QOL during chemotherapy can be planned. This
was a cross-sectional study carried out at the
Hematology-Oncology division Haji Adam Malik
hospital. The research subjects were pediatric ALL
patients aged between 2 and 18 years old, meeting the
inclusion and exclusion criteria. Sampling technique was
consecutive sampling. The relationships between the
dependent variable (QOL) and independent variables
(chemotherapy protocol and duration and side effects)
were assessed by Chi-square, Mann-Whitney, and
Fischer’s exact tests. Multivariate analysis was used to
determine the most dominant independent variable
affecting the QOL of pediatric ALL patients undergoing
chemotherapy. No significant relationship between
chemotherapy protocol and QOL (p=0.435). No
significant relationship between the duration of
chemotherapy and QOL (p>0.05). There were significant
relationships between chemotherapy-induced
gastrointestinal disorder symptoms and QOL, such as
oral mucositis (p=0.001), nausea (p=0.037), vomiting
(p=0.001), and diarrhea (p=0.006). From the multivariate
analysis, three independent variables that could predict
the QOL of pediatric ALL patients were oral mucositis
(p=0.002), nausea (p=0.040), and vomiting (p=0.019).
Chemotherapy procedures for ALL treatment on
pediatric patients showed a poor QOL.
Keywords :
chemotherapy, quality of life, gastrointestinal system, acute lymphoblastic leukemia, pediatric.
