Authors : Pavithra M; Dr. Bhuvaneswari Birla Bose; Dr. Juala Catherine

Volume/Issue : Volume 9 - 2024, Issue 8 - August

Google Scholar : https://tinyurl.com/9dy89nc9

Scribd : https://tinyurl.com/c8y6ebxh

DOI : https://doi.org/10.38124/ijisrt/IJISRT24AUG1423

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Fucoidan, a polysaccharide primarily comprised of l-fucose and sulfate groups possesses a unique chemical structure that underpins its notable therapeutic potential. Its remarkable biological functions such as antioxidant, anticarcinogenic, antiviral, anticoagulant, antithrombotic, immunoregulatory, and anti-inflammatory properties have gained substantial recognition in the global food and pharmaceutical industries. This review highlights recent advancements in understanding fucoidan’s potential biological activities that could innovate treatments for oral infections and inflammatory diseases. A systematic search for relevant articles published between January 2000 and July 2024 was conducted across multiple databases, including PubMed, Scopus, Web of Science, and Google Scholar. Manual searches of references listed in the identified publications were conducted to ensure thorough coverage of the subject. The inclusion criteria focused on peer-reviewed articles in English-language, encompassing meta-analysis, randomized clinical trials, cohort studies, case-control studies and in vitro studies. Exclusion criteria comprised abstracts, opinion pieces, review articles not providing original analysis, and studies not directly addressing the therapeutic effects of fucoidan. This rigorous selection process aims to encapsulate the most significant and recent scientific evidence regarding the therapeutic applications of fucoidan. Fucoidans, with their diverse pharmacological properties, hold promising therapeutic potential which could emerge as a novel therapeutic option for treating wide range of diseases. Fucoidans have demonstrated anti-inflammatory properties, which may be beneficial in reducing inflammation related to periodontal diseases and other oral conditions. We anticipate that this review will serve as a foundational guide and inspire continued product development centered on fucoidan. Clinical relevance to interdisciplinary dentistry:  Fucoidan, a polysaccharide rich in fucose holds wide pharmacological effects  Enhancement of oral health outcomes through anti- inflammatory properties  Antimicrobial activity against oral pathogens  Wound healing property may aid in periodontal diseases.

Keywords : Immunity; Inflammation; Leukocyte; Polysaccharides.

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