HIV continues to be a major health problem globally, claiming 36.3 million lives. In Indonesia alone HIV cases continue to increase cumulatively and Papua is still ranked 6th most cases of people with HIV / AIDS (ODHA). ODHA has a complicated life problem, complex both disease and stigma. This leads to a decrease in the spirit of life which then brings the impact of declining quality of life. The method used is descriptive with a quantitative approach to measure the quality of life with (Word Health Organization Quality Of Life). Result: the most dominant quality of life is the medium category with 44 people; influenced by sex factors (0.000); occupation (0.011); long-suffering marital status (0.048); duration of therapy (0.039); family support (0.001); depression (0.040). Conclusion: people with HIV / AIDS at Polyclinic HIV/AIDS RsudAbepura has the most moderate quality of life and quality of life is influenced by age, gender, occupation, length of suffering, length of therapy, family support and depression.

Keywords : Quality of life, HIV/AIDS.