Authors :
Sowmya BH; Usha Anandhi D
Volume/Issue :
Volume 5 - 2020, Issue 11 - November
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/37N8HXv
Abstract :
The purpose of the current study is to
evaluate the efficacy of Psidium guajava L. (PG) leaf
extract in preventing diabetes-induced oxidative stress in
male albino rats. Induction of Streptozotocin (STZ)
resulted in a significant elevation in lipid peroxidation in
the pancreas of rats. In contrast, the activity of
superoxide dismutase, catalase, and reduced glutathione
activities were significantly reduced in STZ induced
diabetic rats compared to controls. However,
supplementation with 250mg/kg/b.w of leaf extract of PG
for eight weeks, significantly prevented the above
alterations. In contrast, 500 mg/kg/b.w of leaf extract of
PG could not prevent the STZ induced alterations in
antioxidant enzyme activities in diabetic rats. These
results clearly suggest the lower dose of PG leaf extract is
potent enough to prevent oxidative stress in diabetic
male rats.
Keywords :
Psidium guajava L., Streptozotocin, Lipid peroxidation, Catalase.
The purpose of the current study is to
evaluate the efficacy of Psidium guajava L. (PG) leaf
extract in preventing diabetes-induced oxidative stress in
male albino rats. Induction of Streptozotocin (STZ)
resulted in a significant elevation in lipid peroxidation in
the pancreas of rats. In contrast, the activity of
superoxide dismutase, catalase, and reduced glutathione
activities were significantly reduced in STZ induced
diabetic rats compared to controls. However,
supplementation with 250mg/kg/b.w of leaf extract of PG
for eight weeks, significantly prevented the above
alterations. In contrast, 500 mg/kg/b.w of leaf extract of
PG could not prevent the STZ induced alterations in
antioxidant enzyme activities in diabetic rats. These
results clearly suggest the lower dose of PG leaf extract is
potent enough to prevent oxidative stress in diabetic
male rats.
Keywords :
Psidium guajava L., Streptozotocin, Lipid peroxidation, Catalase.
