Authors :
Nadia Mohamed Kermani; Amera Mohamed Aldaek; Fikry Ali Abushofa; Fathia Gadri Jaat
Volume/Issue :
Volume 5 - 2020, Issue 11 - November
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/2UJsReY
Abstract :
Onion (Allium cepa L.) is one of the most
widely consumed and cultivated vegetable crops in the
world, which are effective antioxidants due to their
capability to scavenge free radicals. Potassium bromate is
a chemical additive mixed in flour to improve the action
of gluten and helps to strengthen and soften the dough.
Several studies have shown that a higher amount of
Potassium bromate can cause toxicological effects and
several diseases. The study aims to investigate the
protective and curative effects of red onion extract against
KBrO3 toxicity on hematological, renal function and
histology of the kidney tissues of Wistar rats. 36 Wistar
male rats were divided into 6 batches. Over a 4-week
experimental period, group I rats served as a control and
group II received 100 mg/kg b.w of KBrO3 on the 24th
and 27th days. group III received red onion juice at
1ml/100 g bw every day and 100 mg/kg bw of KBrO3 on
the 24th and 27th days. Group IV received 50 mg/kg bw
of KBrO3 twice per week, group V received red onion
juice daily at 1ml/100 g bw and 50 mg/kg bw of KBrO3
twice per week, and group VI received 30 mg/kg KBrO3
every day. The rats were weighed and sacrificed after
completion of the treatment, and blood was sampled for
haematological and biochemical analysis. The
histopathological investigation was performed for the
kidney tissues of all groups. The results showed a
significant (p<0.05) increase in WBC in groups which
received 30 and 50 mg/kg bw of KBrO3 and a significant
decrease in PLT in the group that received 100 mg/kg bw
of KBrO3 compared to the controls. Additionally,
significant increases in urea, uric acid, creatinine, were
found in all groups treated with KBrO3. However, the
administration of red onion juice along with KBrO3 led to
improvements in the parameters studied.
Histopathological examination of kidney tissue showed
dilation of the Bowman's capsule, haemorrhage,
degeneration, congestion, and necrosis. it is clear that the
toxic effects of KBrO3 were more pronounced in rats
receiving single doses of 100 mg/kg bw. This indicates that
a higher dose leads to worse effects. The results for a
regular dose of 30 mg/kg also indicate the risk of daily
exposure to potassium bromate
Keywords :
Potassium bromate, histopathology, hematology, red onion, kidney, Wistar rats.
Onion (Allium cepa L.) is one of the most
widely consumed and cultivated vegetable crops in the
world, which are effective antioxidants due to their
capability to scavenge free radicals. Potassium bromate is
a chemical additive mixed in flour to improve the action
of gluten and helps to strengthen and soften the dough.
Several studies have shown that a higher amount of
Potassium bromate can cause toxicological effects and
several diseases. The study aims to investigate the
protective and curative effects of red onion extract against
KBrO3 toxicity on hematological, renal function and
histology of the kidney tissues of Wistar rats. 36 Wistar
male rats were divided into 6 batches. Over a 4-week
experimental period, group I rats served as a control and
group II received 100 mg/kg b.w of KBrO3 on the 24th
and 27th days. group III received red onion juice at
1ml/100 g bw every day and 100 mg/kg bw of KBrO3 on
the 24th and 27th days. Group IV received 50 mg/kg bw
of KBrO3 twice per week, group V received red onion
juice daily at 1ml/100 g bw and 50 mg/kg bw of KBrO3
twice per week, and group VI received 30 mg/kg KBrO3
every day. The rats were weighed and sacrificed after
completion of the treatment, and blood was sampled for
haematological and biochemical analysis. The
histopathological investigation was performed for the
kidney tissues of all groups. The results showed a
significant (p<0.05) increase in WBC in groups which
received 30 and 50 mg/kg bw of KBrO3 and a significant
decrease in PLT in the group that received 100 mg/kg bw
of KBrO3 compared to the controls. Additionally,
significant increases in urea, uric acid, creatinine, were
found in all groups treated with KBrO3. However, the
administration of red onion juice along with KBrO3 led to
improvements in the parameters studied.
Histopathological examination of kidney tissue showed
dilation of the Bowman's capsule, haemorrhage,
degeneration, congestion, and necrosis. it is clear that the
toxic effects of KBrO3 were more pronounced in rats
receiving single doses of 100 mg/kg bw. This indicates that
a higher dose leads to worse effects. The results for a
regular dose of 30 mg/kg also indicate the risk of daily
exposure to potassium bromate
Keywords :
Potassium bromate, histopathology, hematology, red onion, kidney, Wistar rats.
